C
Christopher T. Walsh
Researcher at Stanford University
Publications - 841
Citations - 79830
Christopher T. Walsh is an academic researcher from Stanford University. The author has contributed to research in topics: Nonribosomal peptide & Active site. The author has an hindex of 139, co-authored 819 publications receiving 74314 citations. Previous affiliations of Christopher T. Walsh include Florida State University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Action and Timing of BacC and BacD in the Late Stages of Biosynthesis of the Dipeptide Antibiotic Bacilysin
TL;DR: The results suggest the epoxide group in bacilysin is installed in an earlier step of bacallysin biosynthesis, while BacC oxidation of the C(7)-hydroxyl and the subsequent BacD ligation of anticapsin to l-Ala are the penultimate and ultimate steps of b Bacilysin biosynthetic, respectively.
Journal ArticleDOI
Properties of D-amino acid oxidase covalently modified upon its oxidation of D-propargylglycine
TL;DR: A primary kinetic isotope effect is observed upon oxidation of amino acids by the modified enzymes, evidence that this catalysis exhibits a different rate-determining step from catalysis by native enzyme.
Book ChapterDOI
[39] Preparation, characterization, and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin, FMN, and FAD
TL;DR: This chapter discusses the preparation, characterization, and some of the biological and coenzymic properties of the riboflavin analogs, 5-carba-5-deazarib oflavin, and 1-carBA-l-dezariboflavIn at the rib oflav in, flavin mononucleotide (FMN), and flavin adenine dinucleotide levels.
Journal ArticleDOI
d-Ala–d-X ligases: evaluation of d-alanyl phosphate intermediate by MIX, PIX and rapid quench studies
Vicki L Healy,Leisha S. Mullins,Xianfeng Li,Steven E. Hall,Frank M. Raushel,Christopher T. Walsh +5 more
TL;DR: Three approaches support the rapid (more than 1000 min(-1)), reversible formation of the enzyme intermediate D-Ala(1)-P by members of the D-ala-D-X (where X is Ala, Ser or Lac) ligase superfamily.
Journal ArticleDOI
At the Intersection of Chemistry, Biology, and Medicine.
TL;DR: One unanticipated major focus has been investigating the chemical logic and enzymatic machinery of natural product biosynthesis, including antibiotics and antitumor agents in this postgenomic era.