G
Geoffrey Watson
Researcher at Imperial College London
Publications - 13
Citations - 791
Geoffrey Watson is an academic researcher from Imperial College London. The author has contributed to research in topics: Pulmonary hypertension & Iron deficiency. The author has an hindex of 10, co-authored 13 publications receiving 582 citations. Previous affiliations of Geoffrey Watson include National Institutes of Health & Imperial College Healthcare.
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Journal ArticleDOI
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
Evangelos D. Michelakis,Vikram Gurtu,Linda Webster,Gareth Barnes,Geoffrey Watson,Luke Howard,John Cupitt,Ian Paterson,Richard B. Thompson,Kelvin Chow,Declan P. O'Regan,Lan Zhao,John Wharton,David G. Kiely,Adam Kinnaird,Aristeidis E. Boukouris,Christopher W. White,Jayan Nagendran,Darren H. Freed,Stephen J. Wort,J. Simon R. Gibbs,Martin R. Wilkins +21 more
TL;DR: This first-in-human trial of a mitochondria-targeting drug in iPAH demonstrates that PDK is a druggable target and offers hemodynamic improvement in genetically susceptible patients, paving the way for novel precision medicine approaches in this disease.
Journal ArticleDOI
Machine Learning of Three-dimensional Right Ventricular Motion Enables Outcome Prediction in Pulmonary Hypertension: A Cardiac MR Imaging Study.
Timothy J W Dawes,Antonio de Marvao,Wenzhe Shi,Tristan Fletcher,Geoffrey Watson,John Wharton,Christopher J. Rhodes,Luke Howard,J. Simon R. Gibbs,Daniel Rueckert,Stuart A. Cook,Martin R. Wilkins,Declan P. O'Regan +12 more
TL;DR: This work has shown that applying machine learning of complex motion phenotypes obtained from cardiac MR images allows more accurate prediction of patient outcomes in pulmonary hypertension.
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Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.
Christopher J. Rhodes,Pavandeep Ghataorhe,John Wharton,Kevin Rue-Albrecht,Charaka Hadinnapola,Geoffrey Watson,Marta Bleda,Matthias Haimel,Gerry Coghlan,Paul A. Corris,Luke Howard,David G. Kiely,Andrew J. Peacock,Joanna Pepke-Zaba,Mark Toshner,S. John Wort,J. Simon R. Gibbs,Allan Lawrie,Stefan Gräf,Nicholas W. Morrell,Martin R. Wilkins +20 more
TL;DR: Metabolic profiles in PAH are strongly related to survival and should be considered part of the deep phenotypic characterization of this disease.
Journal ArticleDOI
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
Christopher J. Rhodes,John Wharton,Pavandeep Ghataorhe,Geoffrey Watson,Barbara Girerd,Barbara Girerd,Luke Howard,Luke Howard,J. Simon R. Gibbs,J. Simon R. Gibbs,Robin Condliffe,Charles A. Elliot,David G. Kiely,Gérald Simonneau,Gérald Simonneau,David Montani,David Montani,Olivier Sitbon,Olivier Sitbon,Henning Gall,Ralph T. Schermuly,H. Ardeschir Ghofrani,Allan Lawrie,Marc Humbert,Marc Humbert,Martin R. Wilkins +25 more
TL;DR: A combination of nine circulating proteins identifies patients with pulmonary arterial hypertension with a high risk of mortality, independent of existing clinical assessments, and might have a use in clinical management and the evaluation of new therapies.
Journal ArticleDOI
Morphologic and Functional Remodeling of the Right Ventricle in Pulmonary Hypertension by Real Time Three Dimensional Echocardiography
Julia Grapsa,J. Simon R. Gibbs,David Dawson,Geoffrey Watson,Ravi Patni,Thanos Athanasiou,Prakash P Punjabi,Luke Howard,Petros Nihoyannopoulos +8 more
TL;DR: It is demonstrated that different causes of PH may lead to diverse RV remodeling, with the most adverse remodeling being in patients with PAH, and changes of the tricuspid apparatus also differed, withThe most adverse effects seen in Patients with CTED.