Martin Goddard

TL;DR: It is concluded that VSMC apoptosis is 'silent' in normal arteries, which have a large capacity to withstand cell loss, and that SM22α-hDTR Apoe−/− mice may represent an important new model to test agents proposed to stabilize atherosclerotic plaques.

TL;DR: It is concluded that human atherosclerosis is characterized by senescence of VSMCs, accelerated by oxidative stress-induced DNA damage, inhibition of telomerase and marked telomere shortening.

TL;DR: Genome sequencing of hundreds of normal colonic crypts from 42 individuals sheds light on mutational processes and driver mutations in normal colorectal epithelial cells, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colorean epithelium.

TL;DR: The consensus findings from a series of meetings held between 2010-2012 to develop a Working Formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection are reported.

TL;DR: It is concluded that VSMC apoptosis is sufficient to accelerate Atherosclerosis, promote plaque calcification and medial degeneration, prevent expansive remodeling, and promote stenosis in atherosclerosis.