K
Kelvin Chow
Researcher at Siemens
Publications - 93
Citations - 2678
Kelvin Chow is an academic researcher from Siemens. The author has contributed to research in topics: Medicine & Ejection fraction. The author has an hindex of 22, co-authored 80 publications receiving 2001 citations. Previous affiliations of Kelvin Chow include University of Virginia & Northwestern University.
Papers
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Journal ArticleDOI
Saturation recovery single-shot acquisition (SASHA) for myocardial T1 mapping
Kelvin Chow,Jacqueline A. Flewitt,Jacqueline A. Flewitt,Jordin D. Green,Joseph J Pagano,Matthias G. Friedrich,Matthias G. Friedrich,Richard B. Thompson +7 more
TL;DR: A new saturation recovery single‐shot acquisition (SASHA) pulse sequence for T1 mapping and to compare SASHA T1 values in heart failure patients and healthy controls are studied.
Journal ArticleDOI
Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101–Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity
Edith Pituskin,John R. Mackey,Sheri L. Koshman,Davinder S. Jassal,Marshall Pitz,Mark J. Haykowsky,Joseph J Pagano,Kelvin Chow,Richard B. Thompson,Larissa J. Vos,Sunita Ghosh,Gavin Y. Oudit,Justin A. Ezekowitz,D. Ian Paterson +13 more
TL;DR: Perindopril and bisoprolol were well tolerated in patients with HER2-positive early breast cancer who received trastuzumab and protected against cancer therapy-related declines in LVEF; however, trastzumab-mediated left ventricular remodeling-the primary outcome-was not prevented by these pharmacotherapies.
Journal ArticleDOI
Accuracy, precision, and reproducibility of four T1 mapping sequences: a head-to-head comparison of MOLLI, ShMOLLI, SASHA, and SAPPHIRE.
Sébastien Roujol,Sebastian Weingärtner,Murilo Foppa,Kelvin Chow,Keigo Kawaji,Long Ngo,Peter Kellman,Warren J. Manning,Richard B. Thompson,Reza Nezafat +9 more
TL;DR: SASHA and SAPPHIRE yield higher accuracy, lower precision, and similar reproducibility compared with MOLLI and ShMOLLI for T1 measurement and different sequences yield different ECV values; however, all sequences have similar Reproducibility for ECV quantification.
Journal ArticleDOI
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
Evangelos D. Michelakis,Vikram Gurtu,Linda Webster,Gareth Barnes,Geoffrey Watson,Luke Howard,John Cupitt,Ian Paterson,Richard B. Thompson,Kelvin Chow,Declan P. O'Regan,Lan Zhao,John Wharton,David G. Kiely,Adam Kinnaird,Aristeidis E. Boukouris,Christopher W. White,Jayan Nagendran,Darren H. Freed,Stephen J. Wort,J. Simon R. Gibbs,Martin R. Wilkins +21 more
TL;DR: This first-in-human trial of a mitochondria-targeting drug in iPAH demonstrates that PDK is a druggable target and offers hemodynamic improvement in genetically susceptible patients, paving the way for novel precision medicine approaches in this disease.
Journal ArticleDOI
Diffuse myocardial fibrosis by T1-mapping in children with subclinical anthracycline cardiotoxicity: relationship to exercise capacity, cumulative dose and remodeling
Edythe B Tham,Edythe B Tham,Mark J. Haykowsky,Kelvin Chow,Maria Spavor,Sachie Kaneko,Nee S. Khoo,Joseph J Pagano,Andrew S. Mackie,Richard B. Thompson +9 more
TL;DR: Myocardial T1 and ECV were found to be early tissue markers of ventricular remodeling that may represent diffuse fibrosis in children with normal ejection fraction post anthracycline therapy, and are related to cumulative dose, exercise capacity and myocardial wall thinning.