C
Chu-Chiao Chu
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 1
Citations - 395
Chu-Chiao Chu is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: TFEB & Autophagy. The author has an hindex of 1, co-authored 1 publications receiving 299 citations.
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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
Louis R. Lapierre,C. Daniel De Magalhaes Filho,Philip R. McQuary,Chu-Chiao Chu,Orane Visvikis,Jessica T. Chang,Sara Gelino,Binnan Ong,Andrew Davis,Javier E. Irazoqui,Andrew Dillin,Malene Hansen +11 more
TL;DR: It is demonstrated that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan, and a conserved role for HLH -30 and TFEB in autophagy, and possibly longevity is demonstrated.