S
Sara Gelino
Researcher at Discovery Institute
Publications - 13
Citations - 3442
Sara Gelino is an academic researcher from Discovery Institute. The author has contributed to research in topics: Autophagy & Caenorhabditis elegans. The author has an hindex of 11, co-authored 13 publications receiving 2965 citations. Previous affiliations of Sara Gelino include Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan,David B. Shackelford,Maria M. Mihaylova,Sara Gelino,Rebecca A. Kohnz,William B. Mair,Debbie S. Vasquez,Aashish Joshi,Dana M. Gwinn,Rebecca C. Taylor,John M. Asara,James A. J. Fitzpatrick,Andrew Dillin,Benoit Viollet,Mondira Kundu,Malene Hansen,Reuben J. Shaw +16 more
TL;DR: Reconstitution of ULK1-deficient cells with a mutant ULK2 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation.
Journal ArticleDOI
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
Louis R. Lapierre,C. Daniel De Magalhaes Filho,Philip R. McQuary,Chu-Chiao Chu,Orane Visvikis,Jessica T. Chang,Sara Gelino,Binnan Ong,Andrew Davis,Javier E. Irazoqui,Andrew Dillin,Malene Hansen +11 more
TL;DR: It is demonstrated that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan, and a conserved role for HLH -30 and TFEB in autophagy, and possibly longevity is demonstrated.
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Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
TL;DR: A novel mechanism by which autophagy and the lipase LIPL-4 interdependently modulate aging in germline-deficient C. elegans by maintaining lipid homeostasis to prolong life span is offered.
Journal ArticleDOI
Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction.
Sara Gelino,Jessica T. Chang,Caroline Kumsta,Xingyu She,Andrew Davis,Christian Nguyen,Siler H. Panowski,Malene Hansen +7 more
TL;DR: A critical role is shown for autophagy in the intestine, a major metabolic tissue, to ensure lifespan extension of dietary-restricted eat-2 mutants, and intestinal-specific inhibition of autophagosomes leads to a decrease in motility with age.
Journal ArticleDOI
Autophagy - An Emerging Anti-Aging Mechanism.
Sara Gelino,Malene Hansen +1 more
TL;DR: Interestingly, autophagy is induced in a seemingly beneficial manner by many of the same perturbations that extend lifespan, including mutations in key signaling pathways such as the insulin/IGF-1 and TOR pathways.