B
Binnan Ong
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 2
Citations - 443
Binnan Ong is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Caenorhabditis elegans & TFEB. The author has an hindex of 2, co-authored 2 publications receiving 337 citations.
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Journal ArticleDOI
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
Louis R. Lapierre,C. Daniel De Magalhaes Filho,Philip R. McQuary,Chu-Chiao Chu,Orane Visvikis,Jessica T. Chang,Sara Gelino,Binnan Ong,Andrew Davis,Javier E. Irazoqui,Andrew Dillin,Malene Hansen +11 more
TL;DR: It is demonstrated that hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan, and a conserved role for HLH -30 and TFEB in autophagy, and possibly longevity is demonstrated.
Journal ArticleDOI
Integrin‐linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF‐1
Caroline Kumsta,Tsui Ting Ching,Mayuko Nishimura,Andrew Davis,Sara Gelino,Hannah H. Catan,Xiaokun Yu,Chu Chiao Chu,Binnan Ong,Siler H. Panowski,Nathan Baird,Rolf Bodmer,Ao Lin Hsu,Malene Hansen +13 more
TL;DR: Hsf‐1 is identified as a novel effector of the organismal response to reduced ILK levels and ILK inhibition regulates HSF‐1 in a cell nonautonomous fashion to enhance stress resistance and lifespan in C. elegans.