C
Chung-Ming Hsieh
Researcher at AbbVie
Publications - 98
Citations - 7675
Chung-Ming Hsieh is an academic researcher from AbbVie. The author has contributed to research in topics: Vascular smooth muscle & Gene. The author has an hindex of 44, co-authored 98 publications receiving 7417 citations. Previous affiliations of Chung-Ming Hsieh include Brigham and Women's Hospital & Harvard University.
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Journal ArticleDOI
Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis
Jer-Chia Tsai,Mark A. Perrella,Masao Yoshizumi,Chung-Ming Hsieh,Edgar Haber,Robert Schlegel,Mu-En Lee +6 more
TL;DR: The growth-promoting effect of homocysteine on vascular smooth muscle cells, together with its inhibitory effect on endothelial cell growth, represents an important mechanism to explain homocy steine-induced atherosclerosis.
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Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
Ali Hafezi-Moghadam,Tommaso Simoncini,Zequan Yang,Florian P. Limbourg,Jean-Christophe Plumier,Michela C. Rebsamen,Chung-Ming Hsieh,Dao-Shan Chui,Kennard L. Thomas,Alyson Prorock,Victor E. Laubach,Michael A. Moskowitz,Brent A. French,Klaus Ley,James K. Liao +14 more
TL;DR: It is shown that high-dose corticosteroids exert cardiovascular protection through a novel mechanism involving the rapid, non-transcriptional activation of endothelial nitric oxide synthase (eNOS) in wild-type mice.
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Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.
Shaw-Fang Yet,Mark A. Perrella,Matthew D. Layne,Chung-Ming Hsieh,Koji Maemura,Lester Kobzik,Philippe Wiesel,Helen Christou,Stella Kourembanas,Mu-En Lee +9 more
TL;DR: The data suggest that in the absence of HO-1, cardiomyocytes have a maladaptive response to hypoxia and subsequent pulmonary hypertension.
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Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
Tohru Minamino,Helen Christou,Chung-Ming Hsieh,Yuxiang Liu,Vijender Dhawan,Nader G. Abraham,Mark A. Perrella,S. Alex Mitsialis,Stella Kourembanas +8 more
TL;DR: Heme oxygenase-1 transgenic mice were protected from the development of both pulmonary inflammation as well as hypertension and vessel wall hypertrophy induced by hypoxia, suggesting an important protective function of enzymatic products of HO-1 activity as inhibitors of Hypoxia-induced vasoconstrictive and proinflammatory pathways.
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Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells (∗)
Jian Li,Mark A. Perrella,Mark A. Perrella,Jer-Chia Tsai,Shaw-Fang Yet,Chung-Ming Hsieh,Masao Yoshizumi,Cam Patterson,Wilson O. Endege,Fen Zhou,Mu-En Lee +10 more
TL;DR: RNA blot analysis and immunoblot experiments indicate that interleukin-1β induces VEGF gene expression in smooth muscle cells, which indicates that IL-1 β may accelerate the progression of atherosclerotic lesions by promoting the development of new blood vessels.