C
Ciro Ramírez-Suástegui
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 21
Citations - 949
Ciro Ramírez-Suástegui is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Medicine & Cytotoxic T cell. The author has an hindex of 8, co-authored 12 publications receiving 363 citations. Previous affiliations of Ciro Ramírez-Suástegui include University of Bath & National Autonomous University of Mexico.
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Journal ArticleDOI
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4 + T Cells in COVID-19.
Benjamin J Meckiff,Ciro Ramírez-Suástegui,Vicente Fajardo,Serena J Chee,Anthony Kusnadi,Hayley Simon,Simon Eschweiler,Alba Grifoni,Emanuela Pelosi,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Ferhat Ay,Grégory Seumois,Christian H. Ottensmeier,Christian H. Ottensmeier,Christian H. Ottensmeier,Pandurangan Vijayanand,Pandurangan Vijayanand,Pandurangan Vijayanand +19 more
TL;DR: In hospitalized COVID-19 patients, a strong cytotoxic TFH response was observed early in the illness which correlated negatively with antibody levels to SARS-CoV-2 spike protein, and these analyses provide insights into the gene expression patterns of Sars-Cov-2-reactive CD4+ T cells in distinct disease severities.
Journal ArticleDOI
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cells.
Anthony Kusnadi,Ciro Ramírez-Suástegui,Vicente Fajardo,Serena J Chee,Benjamin J Meckiff,Hayley Simon,Emanuela Pelosi,Grégory Seumois,Ferhat Ay,Pandurangan Vijayanand,Pandurangan Vijayanand,Pandurangan Vijayanand,Christian H. Ottensmeier,Christian H. Ottensmeier +13 more
TL;DR: In this article, single-cell transcriptomes of >80,000 virus-reactive CD8+ T cells were obtained using a modified Antigen-Reactive T cell Enrichment (ARTE) assay, from 39 COVID-19 patients and 10 healthy subjects.
Journal ArticleDOI
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
Grégory Seumois,Ciro Ramírez-Suástegui,Benjamin J Schmiedel,Shu Liang,Bjoern Peters,Bjoern Peters,Alessandro Sette,Alessandro Sette,Pandurangan Vijayanand,Pandurangan Vijayanand,Pandurangan Vijayanand +10 more
TL;DR: It is suggested that the THIFNR and TregIFNR subsets may dampen allergic responses, which may help explain why only some people develop TH2 responses to nearly ubiquitous allergens.
Posted ContentDOI
An integrated cell atlas of the human lung in health and disease
Lisa Sikkema,D. Strobl,Luke Zappia,Elo Madissoon,NS Markov,Laure-Emmanuelle Zaragosi,Meshal Ansari,Marie-Jeanne Arguel,Leonie Apperloo,Christophe Bécavin,Marijn Berg,Evgeny Chichelnitskiy,Mei-I Chung,Anna Collin,Aca Gay,Baharak Hooshiar Kashani,Meena Jain,Theodoros Kapellos,TM Kole,Christoph Mayr,Micheal Von Papen,Lance M. Peter,Ciro Ramírez-Suástegui,Janine Schniering,Chase J. Taylor,Thomas Walzthoeni,C Xu,LT Bui,C. De Donno,Leander Dony,Minzhe Guo,AJ Gutierrez,Lukas Heumos,Ni Huang,Ignacio L. Ibarra,Nikki D. Jackson,Preetish Kadur Lakshminarasimha Murthy,Mohammad Lotfollahi,Tracy Tabib,Carlos Talavera-López,Kyle J. Travaglini,Anna Wilbrey-Clark,KB Worlock,Masafumi Yoshida,Tushar J. Desai,Oliver Eickelberg,Caroline Falk,Naftali Kaminski,Mark A. Krasnow,Robert Lafyatis,Marko Nikolic,Joseph E. Powell,Jayaraj Rajagopal,Orit Rozenblatt-Rosen,Max A. Seibold,Dean Sheppard,David Shepherd,Sarah A. Teichmann,Alexander M. Tsankov,Jeffrey A. Whitsett,Y Xu,NE Banovich,Pascal Barbry,Teressa A. Duong,K. Meyer,JA Kropski,Dana Pe'er,H. Schiller,Pramila Tata,JL Schultze,A Iu Misharin,M. Nawijn,Malte D Luecken,Fabian J. Theis +73 more
TL;DR: The integrated Human Lung Cell Atlas (HLCA) is presented, combining 46 datasets of the human respiratory system into a single atlas spanning over 2.2 million cells from 444 individuals across health and disease.
Journal ArticleDOI
Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells
Benjamin J Meckiff,Ciro Ramírez-Suástegui,Vicente Fajardo,Serena J Chee,Anthony Kusnadi,Hayley Simon,Alba Grifoni,Emanuela Pelosi,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Ferhat Ay,Grégory Seumois,Christian H. Ottensmeier,Pandurangan Vijayanand +14 more
TL;DR: Large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4+ T cells from 32 COVID-19 patients provides so far unprecedented insights into the gene expression patterns of SARS-CoV-2 reactive CD4- T cells in distinct disease severities.