C
Clare Lesley Adam
Researcher at University of Aberdeen
Publications - 102
Citations - 4070
Clare Lesley Adam is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 39, co-authored 102 publications receiving 3845 citations. Previous affiliations of Clare Lesley Adam include North Dakota State University & Rowett Research Institute.
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Journal ArticleDOI
Increased maternal nutrition alters development of the appetite-regulating network in the brain
Beverly S. Muhlhausler,Clare Lesley Adam,P.A. Findlay,Jaime A. Duffield,Isabella Caroline McMillen +4 more
TL;DR: Exposure to increased nutrition before birth alters the responses of the central appetite regulatory system to signals of increased adiposity after birth, suggesting that increased maternal nutrition alters development of the appetite‐regulating network in the brain.
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Early origins of obesity: programming the appetite regulatory system.
TL;DR: In this article, a review summarizes recent work on the expression and localization of the "appetite regulatory" peptides in the fetal rodent and sheep hypothalamus and their potential role in the early programming of postnatal appetite and obesity.
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Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake
TL;DR: Circulating concentrations of leptin in sheep correlate with body fatness and are affected by level of food intake and photoperiod, but there was no evidence for a circadian rhythm of plasma leptin, but clear evidence for post-prandial peaks of low amplitude.
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Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression.
Alexander Tups,Claire Ellis,Kim M. Moar,Tracy Logie,Clare Lesley Adam,Julian G. Mercer,Martin Klingenspor,Martin Klingenspor +7 more
TL;DR: The results suggest that the development of leptin resistance in LD-acclimated hamsters involves SOCS3-mediated suppression of leptin signaling in the arcuate nucleus, suggesting that the photoperiod is able to trigger the biannual reversible switch in leptin sensitivity.
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Hypothalamic gene expression in sheep for cocaine- and amphetamine-regulated transcript, pro-opiomelanocortin, neuropeptide Y, agouti-related peptide and leptin receptor and responses to negative energy balance.
TL;DR: Changes in gene expression in the ovine hypothalamus are consistent with responses to the observed reduction in circulation leptin and suggest that the peripheral feedback and central mechanisms for restoring the energy balance may be largely conserved across monogastric and ruminant species.