C
Clare Stirzaker
Researcher at Garvan Institute of Medical Research
Publications - 71
Citations - 7008
Clare Stirzaker is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 36, co-authored 67 publications receiving 5833 citations. Previous affiliations of Clare Stirzaker include Walter and Eliza Hall Institute of Medical Research & St. Vincent's Health System.
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Journal ArticleDOI
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Ruth Pidsley,Ruth Pidsley,Elena Zotenko,Elena Zotenko,Tim J Peters,Mitchell G. Lawrence,Gail P. Risbridger,Peter L. Molloy,Susan Van Djik,Beverly S. Muhlhausler,Clare Stirzaker,Clare Stirzaker,Susan J. Clark,Susan J. Clark +13 more
TL;DR: The EPIC array is a significant improvement over the HM450 array, with increased genome coverage of regulatory regions and high reproducibility and reliability, providing a valuable tool for high-throughput human methylome analyses from diverse clinical samples.
Journal ArticleDOI
Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA
Peter M. Warnecke,Clare Stirzaker,John R. Melki,Douglas Spencer Millar,Cheryl L. Paul,Susan J. Clark,Susan J. Clark +6 more
TL;DR: This study presents a simple method for detection and measurement of PCR bias for any set of primers, and investigates parameters for overcoming PCR bias.
Journal ArticleDOI
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band
Jordi Frigola,Jenny Z. Song,Clare Stirzaker,Rebecca A. Hinshelwood,Miguel A. Peinado,Susan J. Clark +5 more
TL;DR: It is proposed that loss of gene expression can occur through long-range epigenetic silencing, with similar implications as loss of heterozygosity in cancer.
Journal ArticleDOI
Methyl-CpG-binding domain proteins: readers of the epigenome.
TL;DR: The current state of knowledge about MBD proteins and their role as readers of the epigenome is summarized.
Journal ArticleDOI
DNA methylation: bisulphite modification and analysis.
TL;DR: The 'gold-standard' bisulphite conversion protocol that can be used to re-sequence DNA from mammalian cells in order to determine and quantify the methylation state of a gene or genomic region at single-nucleotide resolution is described.