Elena Zotenko

TL;DR: The EPIC array is a significant improvement over the HM450 array, with increased genome coverage of regulatory regions and high reproducibility and reliability, providing a valuable tool for high-throughput human methylome analyses from diverse clinical samples.

TL;DR: A rigorous analysis of six variants of the genomewide protein interaction network for Saccharomyces cerevisiae demonstrated that the majority of hubs are essential due to their involvement in Essential Complex Biological Modules, a group of densely connected proteins with shared biological function that are enriched in essential proteins.

TL;DR: It is found that cancer cells retain the ability to segment their genomes into megabase-sized topologically associated domains (TADs); however, these domains are generally smaller due to establishment of additional domain boundaries.

TL;DR: The data reveal that coordinated hypermethylation can occur in oestrogen receptor-negative disease, and that characterizing the epigenetic framework provides a potential signature to stratify TNBCs, demonstrating the feasibility of profiling the cancer methylome with limited archival tissue to identify regulatory regions associated with cancer.

TL;DR: The DNA methylome of endocrine sensitivity is characterized and the potential impact of differential DNA methylation on endocrine response in breast cancer is demonstrated, showing that DNA hypermethylation occurs predominantly at oestrogen-responsive enhancers and is associated with reduced ESR1 binding and decreased gene expression of key regulators of E SR1 activity.