Jenny Z. Song

TL;DR: It is proposed that loss of gene expression can occur through long-range epigenetic silencing, with similar implications as loss of heterozygosity in cancer.

TL;DR: It is shown that extensive DNA hypermethylation of CpG islands or "CpG-island borders" is strongly related to cancer-specific gene activation or differential promoter usage, which has wide ramifications for cancer diagnosis, progression, and epigenetic-based gene therapies.

TL;DR: It is proposed that consolidation or effective reduction of the cancer genome commonly occurs in domains through a combination of LRES and LOH or genomic deletion, resulting in reduced transcriptional plasticity within these regions.

TL;DR: This work finds that H2A.Z is enriched in a bimodal distribution at nucleosomes, surrounding the transcription start sites (TSSs) of both active and poised gene promoters, and shows for the first time, that acetylation of H 2A.

TL;DR: The data reveal that coordinated hypermethylation can occur in oestrogen receptor-negative disease, and that characterizing the epigenetic framework provides a potential signature to stratify TNBCs, demonstrating the feasibility of profiling the cancer methylome with limited archival tissue to identify regulatory regions associated with cancer.