Claude Jacq

TL;DR: The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration and provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history.

TL;DR: Analysis of mRNA populations associated with free and mitochondrion‐bound polysomes provides new insights into the biogenesis of mitochondria, and finds genes producing mRNAs that are targeted to mitochondria are mainly of ancient bacterial origin, whereas those producing mRNA that are translated in the cytoplasm are mainly in eukaryotic origin.

TL;DR: The cDNA from activated mutants of the homologous transcription factors Pdr1p and Pdr3p was used to screen DNA microarrays of the Saccharomyces cerevisiae complete genome and twenty‐six overexpressed targets of the PDR1–3 and/or PDR3–7 mutants were identified.

TL;DR: MLR, which is intimately linked to translation control, and the activity of mRNA-binding proteins like Puf3p, may provide the conditions for a fine spatiotemporal control of mitochondrial protein import and mitochondrial protein complex assembly.

TL;DR: Evidence that the PDR3 protein is a transcriptional activator was provided by demonstrating that DNA-bound LexA-PDR3 fusion proteins stimulate expression of a nearby promoter containing LexA binding sites, which suggests that the two transcriptional factors have closely related functions.