C
Claudia Canzonetta
Researcher at Imperial College London
Publications - 5
Citations - 1283
Claudia Canzonetta is an academic researcher from Imperial College London. The author has contributed to research in topics: Cellular differentiation & Epigenetics. The author has an hindex of 4, co-authored 5 publications receiving 1213 citations.
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Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms
Vania Parelho,Suzana Hadjur,Mikhail Spivakov,Marion Leleu,Stephan Sauer,Heather C. Gregson,Adam Jarmuz,Claudia Canzonetta,Zoe Webster,Tatyana B. Nesterova,Bradley S. Cobb,Kyoko Yokomori,Niall Dillon,Luis Aragón,Amanda G. Fisher,Matthias Merkenschlager +15 more
TL;DR: It is shown that the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activity, in contrast to S. cerevisiae, and recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because C TCF binding is sensitive to DNA methylation, allows cohesIn positioning to integrate DNA sequence and epigenetic state.
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Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division
Cheok-man Chow,Andrew Georgiou,Henrietta Szutorisz,Alexandra Maia e Silva,Ana Pombo,Isabel Barahona,Elise Dargelos,Claudia Canzonetta,Niall Dillon +8 more
TL;DR: Results suggest that H3.3 is deposited principally through the action of chromatin‐remodelling complexes associated with transcriptional initiation, with deposition mediated by RNA polymerase II elongation having only a minor role.
Journal ArticleDOI
Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.
Henrietta Szutorisz,Claudia Canzonetta,Andrew Georgiou,Cheok-man Chow,Laszlo Tora,Niall Dillon +5 more
TL;DR: It is shown that an intergenic cis-acting element in the mouse λ5-VpreB1 locus is marked by histone H3 acetylation and histone Lysine 4 methylation at a discrete site in embryonic stem (ES) cells, suggesting that localized epigenetic marking is important for establishing the transcriptional competence of the λ 5 and VpreB 1 genes as early as the pluripotent ES cell stage.
Journal ArticleDOI
A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells
Pierangela Sabbattini,Claudia Canzonetta,Marcela Sjoberg,Svetlana Nikic,Andrew Georgiou,Geoffrey Kemball-Cook,Holger W. Auner,Niall Dillon +7 more
TL;DR: It is found that phosphorylation of H3 S10 by Aurora B generates high levels of the double H3K9me3/S10ph modification in differentiated postmitotic cells and also results in delocalisation of HP1β away from heterochromatin in terminally differentiated plasma cells.
A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
Pierangela Sabbattini,Claudia Canzonetta,Marcela Sjoberg,Svetlana Nikic,Andrew Georgiou,Geoffrey Kemball-Cook,Holger W. Auner,Niall Dillon +7 more
TL;DR: In this article, the Aurora B kinase was found to be responsible for generating the double histone H3 modification tri-methylated K9/ phosphorylated S10 (H3K9me3/S10ph), which has been implicated in chromosome condensation during mitosis.