Claudia Fredolini

TL;DR: It is demonstrated that ENOA phosphorylation is associated with PDAC and induces specific autoantibody production in PDAC patients that may have diagnostic value.

TL;DR: Data suggest that a higher proportion of the EGFR mutant carcinoma cells may exhibit activation of the phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (MTOR) pathway through Tyr-1148 and Tyr-1068 and suppression of IRS-1 Ser-612, altered heterodimerization with ERBB2, reduced response to transforming growth factor β suppression, and reduced ubiquitination/degrad

TL;DR: P porous, buoyant, core–shell hydrogel nanoparticles containing novel high affinity reactive chemical baits enabling mass spectrometry (MS) discovery of candidate biomarkers that were previously undetectable are created.

TL;DR: Harvesting core-shell nanoparticles to whole blood for concentration and immediate preservation of low abundance and labile analytes at the time of venipuncture is envisioned.

TL;DR: It seems that metabolic enzymes and cytoskeletal proteins are specific targets of the humoral response during PDAC, and serological-defined antigens could be of diagnostic and therapeutic significance in PDAC.