C
Claudia Policano
Researcher at Sapienza University of Rome
Publications - 8
Citations - 675
Claudia Policano is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Multiple sclerosis & Intestinal permeability. The author has an hindex of 4, co-authored 8 publications receiving 638 citations.
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Journal ArticleDOI
A “candidate-interactome” aggregate analysis of genome-wide association data in multiple sclerosis
Rosella Mechelli,Renato Umeton,Claudia Policano,Viviana Annibali,Giulia Coarelli,Vito A. G. Ricigliano,Danila Vittori,Arianna Fornasiero,Maria Chiara Buscarinu,Silvia Romano,Marco Salvetti,Giovanni Ristori +11 more
TL;DR: The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology, and also other viruses have a similar potential, though probably less relevant in epidemiological terms.
Journal ArticleDOI
Altered intestinal permeability in patients with relapsing–remitting multiple sclerosis: A pilot study
Maria Chiara Buscarinu,Benedetta Cerasoli,Viviana Annibali,Claudia Policano,Luana Lionetto,Matilde Capi,Rosella Mechelli,Silvia Romano,Arianna Fornasiero,Gianluca Mattei,Eleonora Piras,Daniela F. Angelini,Luca Battistini,Maurizio Simmaco,Renato Umeton,Marco Salvetti,Giovanni Ristori +16 more
TL;DR: The relatively high proportion of IP changes in RR-MS patients seems to confirmed the work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations.
Journal ArticleDOI
Epstein-Barr virus genetic variants are associated with multiple sclerosis
Rosella Mechelli,Caterina Manzari,Claudia Policano,Anita Annese,Ernesto Picardi,Renato Umeton,Arianna Fornasiero,Anna Maria D'Erchia,Maria Chiara Buscarinu,Cristina Agliardi,Viviana Annibali,Barbara Serafini,Barbara Rosicarelli,Silvia Romano,Daniela F. Angelini,Vito A. G. Ricigliano,Fabio Buttari,Luca Battistini,Diego Centonze,Franca Rosa Guerini,Sandra D'Alfonso,Graziano Pesole,Marco Salvetti,Giovanni Ristori +23 more
TL;DR: This study unveils a strong association between Epstein-Barr virus genomic variants and MS, reinforcing the idea that Epstein- Barr virus contributes to disease development.
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Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients.
Viviana Annibali,Renato Umeton,Antonia Palermo,Martina Severa,Marilena P. Etna,Simona Giglio,Silvia Romano,Michela Ferraldeschi,Maria Chiara Buscarinu,Andrea Vecchione,Anita Annese,Claudia Policano,Rosella Mechelli,Raffaella Pizzolato Umeton,Arianna Fornasiero,Daniela F. Angelini,Gisella Guerrera,Luca Battistini,Eliana M. Coccia,Marco Salvetti,Giovanni Ristori +20 more
TL;DR: In this paper, the authors performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls and found that IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients.
Journal ArticleDOI
Screening for neurotropic viruses in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases
Rosella Mechelli,Danila Vittori,Giulia Coarelli,Laura Aimati,Ottavia De Luca,Silvia Romano,Vito A. G. Ricigliano,Viviana Annibali,Claudia Policano,Carlo Mattei,Marco Salvetti,Giovanni Ristori +11 more
TL;DR: The relationship between lesion size and EBV-positive PCR seems not to reflect a non-specific recruitment of leucocytes in the central nervous system in the context of amplified inflammation, and the increased chance of detecting EBV DNA in MS patients with more active lesions is instead in accord with Jacobson's group's finding.