Claudio Ramirez

TL;DR: The hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases is supported.

TL;DR: At clinical doses, neither ranibizumab nor aflibercept produced evidence of mitochondrial toxicity or cell death, however, bevacizuab and ziv-aflibercept showed mild mitochondrial toxicity at clinically relevant doses.

TL;DR: Sequencing data suggest that observed effects are not due to rare mtDNA variants but rather the combination of SNPs representing the J versus H haplogroups, representing a paradigm shift in the concepts of mt-nuclear interactions.

TL;DR: The findings demonstrate that mtDNA haplogroup variants mediate not only energy production and cell growth, but also cell signaling for major molecular pathways, including AMD, and support the hypothesis that mt DNA variants play important roles in numerous cellular functions and disease processes.

TL;DR: Genistein, resveratrol, and memantine can reverse the apoptosis and oxidant production generated by B(e)P, a toxic element of smoking, and may be beneficial against retinal diseases associated with the loss of RPE cells.