M
Marilyn Chwa
Researcher at University of California, Irvine
Publications - 73
Citations - 2395
Marilyn Chwa is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Mitochondrial DNA & Haplogroup. The author has an hindex of 26, co-authored 65 publications receiving 2119 citations. Previous affiliations of Marilyn Chwa include University of California & California State University, Long Beach.
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Journal ArticleDOI
Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder.
M. Cristina Kenney,M. Cristina Kenney,Marilyn Chwa,Shari R. Atilano,Annie Tran,Marilee Carballo,Mehrnoosh Saghizadeh,Vasilis Vasiliou,Wakako Adachi,Donald J. Brown +9 more
TL;DR: The findings support the hypothesis that keratoconus corneas undergo oxidative stress and tissue degradation, and elevated levels of cathepsins V/L2, -B, and -G, which can stimulate hydrogen peroxide production, which, in turn, can upregulate catalase, an antioxidant enzyme.
Journal ArticleDOI
Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts.
TL;DR: Stressed KC fibroblasts possessed characteristics similar to those found in the intact KC corneas (increased catalase activity, ROS production, and apoptosis) and may play a role in the pathogenesis of KC.
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Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.
M. Cristina Kenney,Marilyn Chwa,Shari R. Atilano,Payam Falatoonzadeh,Claudio Ramirez,Deepika Malik,Mohamed Tarek,Javier Caceres del Carpio,Anthony B. Nesburn,David S. Boyer,Baruch D. Kuppermann,Marquis P. Vawter,S. Michal Jazwinski,Michael V. Miceli,Douglas C. Wallace,Nitin Udar +15 more
TL;DR: The hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases is supported.
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Evaluation of in vitro effects of bevacizumab (Avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cells.
S. Luthra,Raja Narayanan,L Eduardo A Marques,Marilyn Chwa,Dae W Kim,Joyce Dong,Gail M. Seigel,A. Neekhra,Ana L. Gramajo,Donald J. Brown,M. Cristina Kenney,Baruch D. Kuppermann +11 more
TL;DR: It is suggested that bevacizumab, at concentrations at or above the dose normally used in clinical practice, is not toxic to human retinal pigment epithelial, rat neurosensory retinal, or human microvascular endothelial cells in vitro.
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Mitochondrial DNA Haplogroups Associated with Age-Related Macular Degeneration
Nitin Udar,Shari R. Atilano,M. Memarzadeh,David S. Boyer,Marilyn Chwa,Stephanie Lu,Barak Maguen,Jonathan J. Langberg,Pinar Coskun,Douglas C. Wallace,Anthony B. Nesburn,Anthony B. Nesburn,Nikan H. Khatibi,Dieter Hertzog,Khoi Le,Daniel Hwang,M. Cristina Kenney +16 more
TL;DR: AMD retinas exhibited increased mtDNA control region SNPs compared to normal retinas, consistent with the decline in mitochondrial function with age, and implicate mitochondrial alterations in the etiology of AMD.