Michael V. Miceli

TL;DR: The generation of H2O2 during phagocytosis may act as an intracellular signal in retinal pigment epithelial cells that leads to increased levels of key antioxidant enzymes and other proteins important for protecting the cells from oxidative damage.

TL;DR: ROS phagocytosis subjects RPE cells to an oxidative event on the same order of magnitude as measured in a macrophage, and the enzyme catalase appears to be essential in protecting the RPE cell against reactive oxygen species produced during phagcytosis.

TL;DR: The hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases is supported.

TL;DR: The results demonstrated that, in eyes receiving the noncross-linked collagen support, a layer of pigmented donor retinal pigment epithelium was visible within the subretinal space, with a normal-appearing retina and no evidence of proliferative vitreoretinopathy or graft rejection.

TL;DR: Zinc protected cultured RPE from the toxicity of H2O2 and paraquat, and results show RPE cells cultured in zinc-reduced medium are more susceptible to oxidative insult.