J
Javier Cáceres-del-Carpio
Researcher at University of California, Irvine
Publications - 13
Citations - 275
Javier Cáceres-del-Carpio is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Haplogroup & Mitochondrial DNA. The author has an hindex of 7, co-authored 13 publications receiving 229 citations.
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Journal ArticleDOI
Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial–nuclear interactions
M. Cristina Kenney,Marilyn Chwa,Shari R. Atilano,Payam Falatoonzadeh,Claudio Ramirez,Deepika Malik,Mohamed Tarek,Javier Cáceres-del-Carpio,Anthony B. Nesburn,David S. Boyer,Baruch D. Kuppermann,Marquis P. Vawter,S. Michal Jazwinski,Michael V. Miceli,Douglas C. Wallace,Nitin Udar +15 more
TL;DR: Sequencing data suggest that observed effects are not due to rare mtDNA variants but rather the combination of SNPs representing the J versus H haplogroups, representing a paradigm shift in the concepts of mt-nuclear interactions.
Journal ArticleDOI
Mitochondrial DNA variants can mediate methylation status of inflammation, angiogenesis and signaling genes
Shari R. Atilano,Deepika Malik,Marilyn Chwa,Javier Cáceres-del-Carpio,Anthony B. Nesburn,David S. Boyer,Baruch D. Kuppermann,S. Michal Jazwinski,Michael V. Miceli,Douglas C. Wallace,Nitin Udar,M. Cristina Kenney +11 more
TL;DR: Comparison analyses of human retinal cell cybrids indicate that mtDNA variants can mediate methylation profiles and transcription for inflammation, angiogenesis and various signaling pathways, which are important in several common diseases.
Journal ArticleDOI
Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases
Deepika Malik,Tiffany Hsu,Payam Falatoonzadeh,Javier Cáceres-del-Carpio,Mohamed Tarek,Mohamed Tarek,Marilyn Chwa,Shari R. Atilano,Claudio Ramirez,Anthony B. Nesburn,Anthony B. Nesburn,David S. Boyer,Baruch D. Kuppermann,S. Michal Jazwinski,Michael V. Miceli,Douglas C. Wallace,Nitin Udar,M. Cristina Kenney +17 more
TL;DR: In cells with identical nuclei, the cellular response to sub-lethal UV-radiation is mediated in part by the mtDNA haplogroup, which supports the hypothesis that differences in growth rates and expression levels of complement, inflammation and apoptosis genes may result from population-specific, hereditary SNP variations in mtDNA.
Book ChapterDOI
Corticosteroids: Triamcinolone, Dexamethasone and Fluocinolone
Javier Cáceres-del-Carpio,Rodrigo Donato Costa,Asghar Haider,Raja Narayanan,Baruch D. Kuppermann +4 more
TL;DR: This chapter provides a brief description of the pharmacology, efficacy and adverse effects associated with the use of steroids in various retinal diseases.
Journal ArticleDOI
Brimonidine Can Prevent In Vitro Hydroquinone Damage on Retinal Pigment Epithelium Cells and Retinal Müller Cells.
Claudio Ramirez,Javier Cáceres-del-Carpio,Chu J,Mohamed Tarek Mohamed Moustafa,Marilyn Chwa,Ga Limb,Baruch D. Kuppermann,Maria C. Kenney +7 more
TL;DR: High concentrations of Brimonidine (10×) have minimal damaging effects on human retinal cells and HQ-induced toxicity is mediated through mitochondrial damaging, oxidative stress-related and necrosis-related pathways.