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Clay F. Semenkovich
Researcher at Washington University in St. Louis
Publications - 200
Citations - 33711
Clay F. Semenkovich is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Insulin resistance & Fatty acid synthase. The author has an hindex of 70, co-authored 193 publications receiving 30175 citations. Previous affiliations of Clay F. Semenkovich include Rush University Medical Center & Baylor College of Medicine.
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Journal ArticleDOI
The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model
Heather A. Lawson,Arthur Lee,Gloria L. Fawcett,Bing Wang,L. Susan Pletscher,Taylor J. Maxwell,Thomas H. Ehrich,Jane P. Kenney-Hunt,Jason B. Wolf,Clay F. Semenkovich,James M. Cheverud +10 more
TL;DR: The data demonstrate that the effects of genes on complex trait variation are highly context-dependent and that the same genomic sequence can affect traits differently depending on an individual’s sex and/or dietary environment.
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α2β1 Integrin and Development of Atherosclerosis in a Mouse Model. Assessment of Risk
TL;DR: The results suggest that risk for arterial thrombotic disease associated with high-level &agr;2&bgr;1 integrin expression is not attributable to enhanced development of atherosclerosis per se but may rather be a consequence of thromBotic complications at the plaques.
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Requirement for p38 Mitogen-Activated Protein Kinase Activity in Neointima Formation After Vascular Injury
Brandon M. Proctor,Xiaohua Jin,Traian S. Lupu,Louis J. Muglia,Clay F. Semenkovich,Anthony J. Muslin +5 more
TL;DR: SMC p38α MAPK activation is required for neointima formation, perhaps because of its ability to promote retinoblastoma protein phosphorylation and minichromosome maintenance protein 6 expression.
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Alterations in thigh subcutaneous adipose tissue gene expression in protease inhibitor-based highly active antiretroviral therapy.
Juan Chaparro,Dominic N. Reeds,Weidong Wen,E. Xueping,Samuel Klein,Clay F. Semenkovich,Kyongtae T. Bae,Erin Quirk,William G. Powderly,Kevin E. Yarasheski,Ellen Li +10 more
TL;DR: In the PI group, the messenger RNA expression levels of the CCAAT/enhancer-binding protein alpha, leptin, and adiponectin were significantly lower than the levels measured in the PI-naive group.
Journal ArticleDOI
Absence of Peroxisome Proliferator-Activated Receptor-α Abolishes Hypertension and Attenuates Atherosclerosis in the Tsukuba Hypertensive Mouse
Karen Tordjman,Clay F. Semenkovich,Trey Coleman,Rachel Yudovich,Stella Bak,Etty Osher,Michal Vechoropoulos,Naftali Stern +7 more
TL;DR: The possibility that peroxisome proliferator-activated receptor-&agr; activation may aggravate hypertension and hasten atherosclerosis in the context of an activated renin-angiotensin system is raised.