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Clay F. Semenkovich
Researcher at Washington University in St. Louis
Publications - 200
Citations - 33711
Clay F. Semenkovich is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Insulin resistance & Fatty acid synthase. The author has an hindex of 70, co-authored 193 publications receiving 30175 citations. Previous affiliations of Clay F. Semenkovich include Rush University Medical Center & Baylor College of Medicine.
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Journal ArticleDOI
Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death.
Amy L. Clark,Kohsuke Kanekura,Zeno Lavagnino,Larry D. Spears,Damien Abreu,Jana Mahadevan,Takuya Yagi,Clay F. Semenkovich,David W. Piston,Fumihiko Urano +9 more
TL;DR: In this paper, the authors showed that modulation of cellular calcium homeostasis can mitigate cytokine and ER stress-mediated beta cell death in type 1 diabetes. But, there are no treatments targeting cellular calcium to combat type 1 Diabetes.
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Skeletal muscle lipid flux: running water carries no poison.
TL;DR: Evidence is reviewed that muscle cells are equipped with the molecular machinery to convert and sequester lipid molecules, thus rendering them harmless, and induction of mitochondrial and lipogenic flux in the setting of elevated lipid deposition can protect muscle from lipid-induced "poisoning" of the cellular machinery.
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Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity.
Yuan Wang,Hristo Iordanov,Elzbieta A. Swietlicki,Lihua Wang,Christine Fritsch,Trey Coleman,Clay F. Semenkovich,Marc S. Levin,Marc S. Levin,Deborah C. Rubin +9 more
TL;DR: Transgenic mice generated that specifically overexpress TIS7 in the intestine altered growth, metabolic rate, adiposity, and intestinal triglyceride absorption and these results suggest that Tis7 is a unique mediator of nutrient absorptive and metabolic adaptation following gut resection.
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Quantitative Relationship Between Plasma Lipids and Glycohemoglobin in Type I Patients: Longitudinal Study of 212 Patients
TL;DR: Improved diabetic metabolic control, measured as declining glycohemoglobin, is the variable most closely associated with reduced plasma lipids in a population of typical type I diabetic patients.
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The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice
Charlyn G. Partridge,Charlyn G. Partridge,Gloria L. Fawcett,Gloria L. Fawcett,Bing Wang,Clay F. Semenkovich,James M. Cheverud,James M. Cheverud +7 more
TL;DR: It is suggested that SM/J and its cross with the LG/J strain provide a good model for examining non-alcoholic fatty liver disease and its role in metabolic syndrome.