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Clay F. Semenkovich
Researcher at Washington University in St. Louis
Publications - 200
Citations - 33711
Clay F. Semenkovich is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Insulin resistance & Fatty acid synthase. The author has an hindex of 70, co-authored 193 publications receiving 30175 citations. Previous affiliations of Clay F. Semenkovich include Rush University Medical Center & Baylor College of Medicine.
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Journal ArticleDOI
UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction
Dong-Ho Han,Lorraine A. Nolte,Jeong-Sun Ju,Trey Coleman,John O. Holloszy,Clay F. Semenkovich +5 more
TL;DR: Results suggest that UCP-H mice have a mitochondrial myopathy due to depleted energy stores sufficient to compromise growth and impair muscle function, and suggests that excess intramyocellular lipid and mitochondrial dysfunction are not sufficient to cause insulin resistance in mice.
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ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis
Takashi Izawa,Nidhi Rohatgi,Tomohiro Fukunaga,Qun Tian Wang,Matthew J. Silva,Michael J. Gardner,Michael L. McDaniel,Nada A. Abumrad,Clay F. Semenkovich,Steven L. Teitelbaum,Wei Zou +10 more
TL;DR: ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis and promotes osteoclast mitochondrial biogenesis in a process mediated by PGC-1β but independent of c-Fos.
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FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits
Megan Bowers,Tong Liang,Daniel Gonzalez-Bohorquez,Sara Zocher,Baptiste N. Jaeger,Werner J. Kovacs,Clemens Röhrl,Kaitlyn M.L. Cramb,Jochen Winterer,Merit Kruse,Slavica Dimitrieva,Rupert W. Overall,Thomas Wegleiter,Hossein Najmabadi,Clay F. Semenkovich,Gerd Kempermann,Csaba Földy,Sebastian Jessberger +17 more
TL;DR: Analysis of links between lipid metabolism and cognitive function in mice and human embryonic stem cells expressing mutant fatty acid synthase (FASN; R1819W) suggests that altered lipid metabolism contributes to intellectual disability.
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Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy.
TL;DR: Lovastatin therapy in CESD appears to be clinically beneficial and has complex effects on lipid metabolism that may include a dominant inhibitory effect on hepatic lipoprotein production, posttranscriptionally mediated induction of the LDL receptor, and alterations of LDL particles that interfere with their clearance by the LDL receptors in vivo.
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The role of osteoprogenitors in vascular calcification.
TL;DR: Studies of the effects of diabetes mellitus, hyperlipidemia, estrogens and glucocorticoids on calcifying vascular cell function provide insight into the relationship between common human disease states and vascular calcification.