C
Clement Hamani
Researcher at University Health Network
Publications - 80
Citations - 9915
Clement Hamani is an academic researcher from University Health Network. The author has contributed to research in topics: Deep brain stimulation & Medicine. The author has an hindex of 30, co-authored 51 publications receiving 9030 citations. Previous affiliations of Clement Hamani include Centre for Addiction and Mental Health & Toronto Western Hospital.
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Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
Journal ArticleDOI
Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression.
Andres M. Lozano,Helen S. Mayberg,Helen S. Mayberg,Peter Giacobbe,Clement Hamani,R. Cameron Craddock,Sydney H. Kennedy +6 more
TL;DR: This study suggests that DBS is relatively safe and provides significant improvement in patients with TRD and likely acts by modulating brain networks whose dysfunction leads to depression.
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A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
Adrian W. Laxton,David F. Tang-Wai,David F. Tang-Wai,Mary Pat McAndrews,Dominik Zumsteg,Richard Wennberg,Ron Keren,John Wherrett,John Wherrett,Gary Naglie,Clement Hamani,Gwenn S. Smith,Andres M. Lozano +12 more
TL;DR: It is hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits in Alzheimer's disease.
Journal ArticleDOI
Memory enhancement induced by hypothalamic/fornix deep brain stimulation.
Clement Hamani,Mary Pat McAndrews,Melanie Cohn,Michael Oh,Dominik Zumsteg,Colin M. Shapiro,Richard Wennberg,Andres M. Lozano +7 more
TL;DR: Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures, which shows that hypothalamus stimulation in this patient modulates limbic activity and improves certain memory functions.
Journal ArticleDOI
The Subcallosal Cingulate Gyrus in the Context of Major Depression
Clement Hamani,Clement Hamani,Helen S. Mayberg,Scellig S D Stone,Adrian W. Laxton,Suzanne N. Haber,Andres M. Lozano +6 more
TL;DR: The anatomic and histologic attributes of the SCG and the morphologic and imaging changes observed in depression are reviewed and particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region.