D
David F. Tang-Wai
Researcher at University of Toronto
Publications - 159
Citations - 7143
David F. Tang-Wai is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Frontotemporal dementia. The author has an hindex of 35, co-authored 115 publications receiving 5910 citations. Previous affiliations of David F. Tang-Wai include University of Rochester & Centre for Addiction and Mental Health.
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Journal ArticleDOI
A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease
Adrian W. Laxton,David F. Tang-Wai,David F. Tang-Wai,Mary Pat McAndrews,Dominik Zumsteg,Richard Wennberg,Ron Keren,John Wherrett,John Wherrett,Gary Naglie,Clement Hamani,Gwenn S. Smith,Andres M. Lozano +12 more
TL;DR: It is hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits in Alzheimer's disease.
Journal ArticleDOI
Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
David F. Tang-Wai,Neill R. Graff-Radford,B. F. Boeve,Dennis W. Dickson,Joseph E. Parisi,Richard Crook,Richard J. Caselli,D. S. Knopman,R. C. Petersen +8 more
TL;DR: PCA is a distinctive dementia syndrome in which the most pronounced pathologic involvement is in the occipitoparietal regions independent of the specific underlying pathology.
Journal ArticleDOI
Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis
Jonathan D. Rohrer,Jennifer M. Nicholas,Jennifer M. Nicholas,David M. Cash,John C. van Swieten,Elise G.P. Dopper,Lize C. Jiskoot,Rick van Minkelen,Serge A.R.B. Rombouts,M. Jorge Cardoso,Shona Clegg,Miklos Espak,Simon Mead,David L. Thomas,Enrico De Vita,Mario Masellis,Sandra E. Black,Morris Freedman,Ron Keren,Bradley J. MacIntosh,Ekaterina Rogaeva,David F. Tang-Wai,Maria Carmela Tartaglia,Robert Laforce,Fabrizio Tagliavini,Pietro Tiraboschi,Veronica Redaelli,Sara Prioni,Marina Grisoli,Barbara Borroni,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Andrea Arighi,Giorgio G. Fumagalli,James B. Rowe,Ian Coyle-Gilchrist,Caroline Graff,Caroline Graff,Marie Fallström,Vesna Jelic,Vesna Jelic,Anne Kinhult Ståhlbom,Anne Kinhult Ståhlbom,Christin Andersson,Christin Andersson,Håkan Thonberg,Håkan Thonberg,Lena Lilius,Giovanni B. Frisoni,Giuliano Binetti,Michela Pievani,Martina Bocchetta,Luisa Benussi,Roberta Ghidoni,Elizabeth Finger,Sandro Sorbi,Benedetta Nacmias,Gemma Lombardi,Cristina Polito,Jason D. Warren,Sebastien Ourselin,Nick C. Fox,Martin N. Rossor +63 more
TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.
Journal ArticleDOI
Consensus classification of posterior cortical atrophy
Sebastian J. Crutch,Jonathan M. Schott,Gil D. Rabinovici,Melissa E. Murray,Julie S. Snowden,Julie S. Snowden,Wiesje M. van der Flier,Bradford C. Dickerson,Rik Vandenberghe,Samrah Ahmed,Thomas H. Bak,Bradley F. Boeve,Christopher C Butler,Stefano F. Cappa,Mathieu Ceccaldi,Leonardo Cruz de Souza,Bruno Dubois,Olivier Felician,Douglas Galasko,Jonathan Graff-Radford,Neill R. Graff-Radford,Patrick R. Hof,Pierre Krolak-Salmon,Manja Lehmann,Manja Lehmann,Eloi Magnin,Mario F. Mendez,Peter J. Nestor,Chiadi U. Onyike,Victoria S. Pelak,Yolande A.L. Pijnenburg,Silvia Primativo,Martin N. Rossor,Natalie S. Ryan,Philip Scheltens,Timothy J. Shakespeare,Aida Suarez Gonzalez,David F. Tang-Wai,Keir X.X. Yong,Maria C. Carrillo,Nick C. Fox +40 more
TL;DR: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.
Journal ArticleDOI
Comparison of memory fMRI response among normal, MCI, and Alzheimer’s patients
Mary M. Machulda,Heidi A. Ward,Brett J. Borowski,Jeffrey L. Gunter,Ruth H. Cha,P. C. O'Brien,Ronald C. Petersen,B. F. Boeve,D. S. Knopman,David F. Tang-Wai,Robert J. Ivnik,Glenn E. Smith,Eric G. Tangalos,C. R. Jack +13 more
TL;DR: In this article, the authors used receiver operating characteristic (ROC) analyses to determine whether an fMRI memory encoding task distinguishes among cognitively normal elderly individuals, patients with mild cognitive impairment (MCI), and patients with early Alzheimer's disease (AD).