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Cole Trapnell
Researcher at University of Washington
Publications - 148
Citations - 101469
Cole Trapnell is an academic researcher from University of Washington. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 57, co-authored 123 publications receiving 84590 citations. Previous affiliations of Cole Trapnell include Iowa State University & Massachusetts Institute of Technology.
Papers
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Posted ContentDOI
High-Capacity Sample Multiplexing for Single Cell Chromatin Accessibility Profiling
Gregory T. Booth,Riza M. Daza,Sanjay Srivatsan,José L. McFaline-Figueroa,Rula J Green Gladden,Scott N. Furlan,Jay Shendure,Cole Trapnell +7 more
TL;DR: In this paper , a novel approach, called sciPlex-ATAC-seq, was proposed to simultaneously profile chromatin accessibility within single nuclei from virtually unlimited specimens or experimental conditions.
Posted ContentDOI
Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis
Yoshihiro Hasegawa,Jennifer M. Franks,Y. Tanaka,Yasuaki Uehara,David F. Read,Claire R. Williams,Sanjay Srivatsan,Lori B. Pitstick,Nikolaos M. Nikolaidis,Ciara M. Shaver,Huixing Wu,Jason D. Gardner,Andrew R. Osterburg,Jane J. Yu,Elizabeth J. Kopras,Steven L. Teitelbaum,Kathryn A. Wikenheiser-Brokamp,Cole Trapnell,Francis X. McCormack +18 more
TL;DR: In this paper , the authors explored the mechanisms of silica-induced pulmonary fibrosis in a mouse model using multiple modalities including whole-lung single-nucleus RNA sequencing.
Patent
High-throughput single-nuclei and single-cell libraries and methods of making and of using
Sanjay Srivatsan,José L. McFaline-Figueroa,Vijay Ramani,Junyue Cao,Booth Gregory,Jay Shendure,Cole Trapnell,Steemers Frank J +7 more
TL;DR: In this paper, the authors present methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells, including normalization hashing and nuclear or cellular hashing, which aids in estimating and removing technical noise in cell to cell variation and increases sensitivity and specificity.
Posted ContentDOI
Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing
Tomer Itkin,Sean Houghton,Ryan Schreiner,Yang Lin,Chaitanya R. Badwe,Veronique Voisin,Alex Murison,Negar Seyedhassantehrani,Laura García-Prat,Gregory T. Booth,Fuqiang Geng,Ying Liu,Jesús M. Gómez-Salinero,Jae-Hung Shieh,David Redmond,Jenny Xiang,Steven Z. Josefowicz,Cole Trapnell,Joel A. Spencer,Lior Zangi,Brandon Hadland,John E. Dick,Stephanie Z. Xie,Shahin Rafii +23 more
TL;DR: In this paper , the authors reveal that Fli-1 activity is essential for HSCs during regenerative hematopoiesis, and apply FLI-1 modified-mRNA transduction into lethargic adult human mobilized HSPCs, enabling their vigorous niche-mediated expansion along with superior engraftment capacities.
Proceedings ArticleDOI
GM-CSF Signaling Deficiency Causes the Arrest of Alveolar Macrophage Differentiation and Perturbs Pulmonary Lymphocyte Homeostasis
Bruce C. Trapnell,Paritha Arumugam,Clark B. Williams,D. Read,Mario Moreno Mantilla,Sanjay Srivatsan,Matthew Wessendarp,Y. Ma,Brenna Carey,Cole Trapnell +9 more