C
Cole Trapnell
Researcher at University of Washington
Publications - 148
Citations - 101469
Cole Trapnell is an academic researcher from University of Washington. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 57, co-authored 123 publications receiving 84590 citations. Previous affiliations of Cole Trapnell include Iowa State University & Massachusetts Institute of Technology.
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Single cell, whole embryo phenotyping of pleiotropic disorders of mammalian development
Xingfan Huang,Jan-Olav Henck,Chengxiang Qiu,Varun K. A. Sreenivasan,Saranya Balachandran,R. Behncke,Wing Lee Chan,Alexandra Friederike Despang,Diane E. Dickel,Natja Haag,René Hägerling,Nils R. Hansmeier,Friederike Hennig,Cooper Marshall,Sudha Rajderkar,Alessa R. Ringel,Michael I. Robson,Lauren M. Saunders,Sanjay Srivatsan,Sascha Ulferts,Lars Wittler,Yiwen Zhu,Vera M. Kalscheuer,Daniel M. Ibrahim,Ingo Kurth,Uwe Kornak,David R. Beier,Axel Visel,Len A. Pennacchio,Cole Trapnell,Junyue Cao,Jay Shendure,Malte Spielmann +32 more
TL;DR: Overall, the findings show how single cell profiling of whole embryos can enable the systematic molecular and cellular phenotypic characterization of mouse mutants with unprecedented breadth and resolution.
Posted ContentDOI
Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes
Tuo Shi,Marielle Beaulieu,Lauren M. Saunders,Péter Imre Fábián,Cole Trapnell,Neil Segil,Justin Gage Crump,David W. Raible +7 more
TL;DR: It is suggested that primitive specialization of spatially distinct striolar and extrastriolar hair cells likely arose in the last common ancestor of fish and mammals.
Journal ArticleDOI
CRISPR-Cas9 Screens Reveal Genes Regulating a G0-Like State in Human Neural Progenitors
Heather Feldman,Chad M. Toledo,Sonali Arora,Pia Hoellerbauer,Philip Corrin,Lucas Carter,Megan Kufeld,Hamid Bolouri,Ryan Basom,Jeffrey J. Delrow,Joshua Meier,Feng Zhang,José L. McFaline-Figueroa,Cole Trapnell,Steven M. Pollard,Christopher L. Plaisier,Patrick J. Paddison +16 more
TL;DR: In this paper, the authors performed CRISPR-Cas9 screens and identified genes that limit the expansion of human neural progenitor cells (hNPCs) via skipping of a transient G0-like state, accompanied by transcriptional reprogramming.
Posted ContentDOI
Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication
E. R. Vanderwall,Kaitlyn A Barrow,L.M. Rich,David F. Read,Cole Trapnell,Oghenemega Okoloko,Steven F. Ziegler,Teal S. Hallstrand,M.P. White,Jason S Debley +9 more
TL;DR: In this article, the authors compared IFN I/III responses to SARS-CoV-2 and HRV-16, and assessed whether pre-infection with HRV16, or pretreatment with recombinant IFN-{beta} or IFN{lambda}, modified SARSCoV2 replication.
Posted ContentDOI
Proteostasis governs differential temperature sensitivity across embryonic cell types
Michael W. Dorrity,Lauren M. Saunders,Madeleine Duran,Sanjay Srivatsan,Brent Ewing,Christine Queitsch,Jay Shendure,David W. Raible,David Kimelman,Cole Trapnell +9 more
TL;DR: This study characterize hundreds of individual zebrafish embryos under temperature stress using whole-animal single cell RNA-seq to identify cell types and molecular programs within them that drive phenotypic variability and shows that the notochord is particularly sensitive to temperature stress.