Cole Trapnell

TL;DR: Application of this method to hypothalamic neurons controlling physiological responses to fear and stress reveal subsets of upstream neurons that express diverse constellations of signaling molecules and can be distinguished by their anatomical locations.

TL;DR: The power of shotgun single cell profiling of embryos to resolve dynamic changes in open chromatin during development, and to uncover the cis-regulatory programs of germ layers and cell types are demonstrated.

TL;DR: The 2019 Keystone eSymposium "Single Cell Biology" as discussed by the authors discussed advances both in single cell applications and technologies, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming.

TL;DR: A comprehensive map of the accessible chromatin landscape of the mouse hippocampus at single-cell resolution is presented, shedding light on key dynamic loci that reconfigure to specify hippocampal cell lineages.

TL;DR: This work presents Visual Cell Sorting, a method that physically separates hundreds of thousands of live cells based on their visual phenotype, and uses it to recover cells that retain normal nuclear morphologies after paclitaxel treatment, then derive their single cell transcriptomes to identify multiple pathways associated with pac litaxel resistance in human cancers.