Cole Trapnell

TL;DR: In this paper, single cell transcriptomes of zebrafish with genetic or induced defects in pigmentation and squamation were analyzed to reveal a previously undescribed population of ameloblast-like epidermal cells, suggest hormonal control of epithelial-mesenchymal signaling, clarify the signaling network that governs scale papillae development, and identify the hypodermis as a crucial pigment cell support environment.

TL;DR: The results suggest that hNPC expansion is constrained by a transient G0-like state, regulated by multiple pathways, that facilitates retention of neurodevelopmental identity.

TL;DR: In the version of this article initially published, in Table 1, Steven Salzberg should have been listed as the second, and not the last, of the creators of the Cufflinks software.

TL;DR: Combining the transcriptional profiles of emerging HSC with niche AGM-EC, candidate ligand-receptor pairs regulating intercellular interactions during HSC specification and self-renewal are identified and validated and are expected to enhance the understanding of the unique signal pathways necessary for the development of functional HSC.

TL;DR: The authors showed that rare HE with functional HSC potential in the early murine embryo are distinct from more abundant HE with multilineage hematopoietic potential that fail to generate HSC.