Cole Trapnell

TL;DR: This study highlights molecular mechanisms by which alternative splicing and miRNA-mediated post-transcriptional regulation impact the molecular identity and stage-specific developmental features of human HSCs.

TL;DR: The data indicate iPSC-Mφ as a source of functional macrophages displaying substantial plasticity and therapeutic potential that upon pulmonary transplantation will integrate into the lung microenvironment, adopt an AMφ phenotype and gene expression pattern, and profoundly ameliorate pulmonary disease phenotypes.

TL;DR: This work presents Visual Cell Sorting, a method that physically separates hundreds of thousands of live cells based on their visual phenotype, and uses it to assess hundreds ofnuclear localization sequence variants in a pooled format, identifying variants that improve nuclear localization and enabling annotation of nuclear localization sequences in thousands of human proteins.

TL;DR: Creators of software widely used in computational biology discuss the factors that contributed to their success and suggest ideas for future generations of software developers.