C
Cong Ruth
Researcher at University of Massachusetts Amherst
Publications - 7
Citations - 514
Cong Ruth is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Voltage-dependent calcium channel & Calcium channel. The author has an hindex of 5, co-authored 7 publications receiving 493 citations.
Papers
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Journal ArticleDOI
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.
Robert Newcomb,Balazs G. Szoke,Andrew Palma,Gang Wang,Xiao-hua Chen,William F. Hopkins,Cong Ruth,James A. Miller,Laszlo Urge,Katalin Tarczy-Hornoch,Joseph A. Loo,David J. Dooley,Laszlo Nadasdi,Richard W. Tsien,José R. Lemos,George P. Miljanich +15 more
TL;DR: The unique selectivity of SNX-482 suggests its usefulness in studying the diversity, function, and pharmacology of class E and/or R-type Ca2+ channels.
Journal ArticleDOI
SNX-325, a novel calcium antagonist from the spider Segestria florentina.
Robert Newcomb,Andrew Palma,J Fox,S. Gaur,K Lau,Daniel C. Chung,Cong Ruth,J.R. Bell,B Horne,Laszlo Nadasdi +9 more
TL;DR: SNX-325 will be a useful comparative tool in further defining the function and pharmacology of the N- and possibly other types of high-voltage activated calcium channels.
Patent
Dna encoding a human calcium channel alpha-1e subunit
TL;DR: Isolated DNA encoding a human neuronal calcium channel alpha-1 subunit of subtype E and its corresponding polypeptide is disclosed in this article, as well as methods for screening for therapeutic compounds, using such compositions.
Patent
Voltage-gated calcium channel antagonist and methods
Robert Newcomb,Andrew Palma,Balazs G. Szoke,Katalin Tarczy-Hornoch,William F. Hopkins,Cong Ruth,George P. Miljanich,Robin Dean,Laszlo Nadasdi,Laszlo Urge,Stephen S. Bowersox +10 more
TL;DR: A novel class of peptides selectively block class E voltage-gated calcium channels as mentioned in this paper, which is exemplified by HG peptides such as HG-1, which was isolated from the venom-producing cells of the tarantula Hysterocrates gigas.
Journal ArticleDOI
SNX‐482: A Novel Class E Calcium Channel Antagonist from Tarantula Venom
Robert Newcomb,Xiaohua Chen,Robin Dean,Govindin Dayanithi,Cong Ruth,Balazs G. Szoke,José R. Lemos,S. Scott Bowersox,George P. Miljanich +8 more
TL;DR: The peptide possesses antiseizure activity in several animal models of epilepsy, suggesting that class E antagonists may have pharmacological use in seizure disorders and a possible utility for SNX-482 as a neuroendocrine modulator.