J
José R. Lemos
Researcher at Worcester Foundation for Biomedical Research
Publications - 19
Citations - 1439
José R. Lemos is an academic researcher from Worcester Foundation for Biomedical Research. The author has contributed to research in topics: Patch clamp & Voltage-dependent calcium channel. The author has an hindex of 14, co-authored 19 publications receiving 1402 citations. Previous affiliations of José R. Lemos include University of Massachusetts Amherst & University of Nice Sophia Antipolis.
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Journal ArticleDOI
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.
Robert Newcomb,Balazs G. Szoke,Andrew Palma,Gang Wang,Xiao-hua Chen,William F. Hopkins,Cong Ruth,James A. Miller,Laszlo Urge,Katalin Tarczy-Hornoch,Joseph A. Loo,David J. Dooley,Laszlo Nadasdi,Richard W. Tsien,José R. Lemos,George P. Miljanich +15 more
TL;DR: The unique selectivity of SNX-482 suggests its usefulness in studying the diversity, function, and pharmacology of class E and/or R-type Ca2+ channels.
Journal ArticleDOI
Two types of calcium channels coexist in peptide-releasing vertebrate nerve terminals.
José R. Lemos,Martha C. Nowyckyt +1 more
TL;DR: Using both single-channel and whole-cell patch-clamp techniques, two types of Ca2+ channels are characterized that coexist in these terminals, one of which is a large-conductance, high-threshold, dihydropyridine-sensitive channel that contributes a slowly inactivating current and the other a smaller conductance channel, which is also activated at high thresholds, but underlies a rapidly inactivates, diHydropyrazine-insensitive current.
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Interaction of SNX482 with Domains III and IV Inhibits Activation Gating of α1E (CaV2.3) Calcium Channels
Emmanuel Bourinet,Stephanie C. Stotz,Renee L. Spaetgens,Govindan Dayanithi,José R. Lemos,Joël Nargeot,Gerald W. Zamponi +6 more
TL;DR: SNX482 does not exhibit unequivocal specificity for R-type channels, but highly effectively antagonizes their activation, suggesting that the toxin inhibits alpha(1E) calcium channels by preventing their activation.
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Role of Q-type Ca2+ Channels in Vasopressin Secretion From Neurohypophysial Terminals of the Rat
Gang Wang,Govindan Dayanithi,Sinnei Kim,Dennis Hom,Laszlo Nadasdi,Ramasharma Kristipati,J. Ramachandran,Edward L. Stuenkel,Jean J. Nordmann,Robert Newcomb,José R. Lemos +10 more
TL;DR: Q‐channels are present on a subset of the neurohypophysial terminals where, in combination with N‐ and L‐ch channels, they control AVP but not OT peptide neurosecretion.
Journal ArticleDOI
Voltage‐dependent modulation of T‐type calcium channels by protein tyrosine phosphorylation
TL;DR: The positive and negative modulation of this channel by the tyrosine phosphorylation state provides a plausible mechanism for the control of sperm activity during the early stages of mammalian fertilization.