Journal ArticleDOI
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.
Robert Newcomb,Balazs G. Szoke,Andrew Palma,Gang Wang,Xiao-hua Chen,William F. Hopkins,Cong Ruth,James A. Miller,Laszlo Urge,Katalin Tarczy-Hornoch,Joseph A. Loo,David J. Dooley,Laszlo Nadasdi,Richard W. Tsien,José R. Lemos,George P. Miljanich +15 more
TLDR
The unique selectivity of SNX-482 suggests its usefulness in studying the diversity, function, and pharmacology of class E and/or R-type Ca2+ channels.Abstract:
We describe the first potent and selective blocker of the class E Ca2+channel. SNX-482, a novel 41 amino acid peptide present in the venom of the African tarantula, Hysterocrates gigas, was identif...read more
Citations
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International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
TL;DR: The molecular relationships and physiological functions of these calcium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided.
Journal ArticleDOI
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
TL;DR: The goal of this review is to provide a comprehensive description of T-type currents, their distribution, regulation, pharmacology, and cloning.
Journal ArticleDOI
Voltage-Gated Calcium Channels
TL;DR: The molecular relationships and physiological functions of these voltage-gated Ca(2+) channel proteins are presented and information on their molecular, genetic, physiological, and pharmacological properties is provided.
Journal ArticleDOI
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential
TL;DR: This review describes how use-dependent blockers of the different isoforms could selectively block calcium channels in particular pathologies, such as nociceptive neurons in pain states or in epileptic brain circuits, and describes how selectivity for different subtypes of calcium channels may be achieved in the future.
Journal ArticleDOI
Therapeutic potential of venom peptides
Richard J. Lewis,Maria L. Garcia +1 more
TL;DR: The pharmacology of venom peptides is surveyed and their therapeutic prospects are assessed for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases are assessed.
References
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