R
Robert Newcomb
Researcher at University of Hawaii
Publications - 17
Citations - 1054
Robert Newcomb is an academic researcher from University of Hawaii. The author has contributed to research in topics: Voltage-dependent calcium channel & Peptide. The author has an hindex of 12, co-authored 17 publications receiving 1026 citations. Previous affiliations of Robert Newcomb include University of Massachusetts Amherst.
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Journal ArticleDOI
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.
Robert Newcomb,Balazs G. Szoke,Andrew Palma,Gang Wang,Xiao-hua Chen,William F. Hopkins,Cong Ruth,James A. Miller,Laszlo Urge,Katalin Tarczy-Hornoch,Joseph A. Loo,David J. Dooley,Laszlo Nadasdi,Richard W. Tsien,José R. Lemos,George P. Miljanich +15 more
TL;DR: The unique selectivity of SNX-482 suggests its usefulness in studying the diversity, function, and pharmacology of class E and/or R-type Ca2+ channels.
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An R-type Ca(2+) current in neurohypophysial terminals preferentially regulates oxytocin secretion.
TL;DR: The results suggest that an α1E or “R”-type Ca2+ channel exists in oxytocinergic nerve terminals and, thus, functions in controlling only Oxytocin release from the rat neurohypophysis.
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Role of Q-type Ca2+ Channels in Vasopressin Secretion From Neurohypophysial Terminals of the Rat
Gang Wang,Govindan Dayanithi,Sinnei Kim,Dennis Hom,Laszlo Nadasdi,Ramasharma Kristipati,J. Ramachandran,Edward L. Stuenkel,Jean J. Nordmann,Robert Newcomb,José R. Lemos +10 more
TL;DR: Q‐channels are present on a subset of the neurohypophysial terminals where, in combination with N‐ and L‐ch channels, they control AVP but not OT peptide neurosecretion.
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Purification and amino acid composition of a peptide with molt-inhibiting activity from the lobster, Homarus americanus.
TL;DR: A peptide was isolated and purified from sinus glands of the lobster, Homarus americanus, that was able to decrease circulating titers of ecdysteroids and increase the molt interval of eyestalk-ablated juvenile lobsters.
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Peptides in the sinus gland ofCardisoma carnifex: isolation and amino acid analysis
TL;DR: Reversed phase liquid chromatography (RPLC) has been used to isolate most of the peptides in the sinus gland of the land crabCardisoma carnifex, and high sensitivity peptide maps were obtained by RPLC ofThe peptide fluoreseamine derivatives.