C
Cong Yan
Researcher at Indiana University
Publications - 73
Citations - 3933
Cong Yan is an academic researcher from Indiana University. The author has contributed to research in topics: Myeloid & Inflammation. The author has an hindex of 28, co-authored 68 publications receiving 3343 citations. Previous affiliations of Cong Yan include Huazhong University of Science and Technology & Boston Children's Hospital.
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Journal ArticleDOI
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Stanley Ching-Cheng Huang,Bart Everts,Yulia Ivanova,David O’Sullivan,Marcia Nascimento,Amber M. Smith,Wandy L. Beatty,Latisha Love-Gregory,Wing Y. Lam,Christina M. O’Neill,Cong Yan,Hong Du,Nada A. Abumrad,Joseph F. Urban,Maxim N. Artyomov,Erika L. Pearce,Edward J. Pearce +16 more
TL;DR: In this article, the authors found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation
Stanley Ching-Cheng Huang,Bart Everts,Yulia Ivanova,David O’Sullivan,Marcia Nascimento,Amber M. Smith,Wandy L. Beatty,Latisha Love-Gregory,Wing Y. Lam,Christina M. O’Neill,Cong Yan,Hong Du,Nada A. Abumrad,Joseph F. Urban,Maxim N. Artyomov,Erika L. Pearce,Edward J. Pearce +16 more
TL;DR: It is found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Journal ArticleDOI
CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation
Vinit Kumar,Pingyan Cheng,Thomas Condamine,Sridevi Mony,Lucia R. Languino,Judith C. McCaffrey,Neil G. Hockstein,Michael J. Guarino,Gregory A. Masters,Emily Penman,Fred Denstman,Xiaowei Xu,Dario C. Altieri,Hong Du,Cong Yan,Dmitry I. Gabrilovich +15 more
TL;DR: iteration of TAMs in tumor site from monocytic precursors was controlled by downregulation of the activity of the transcription factor STAT3, which has a unique function in the tumor environment in controlling the differentiation of MDSC into TAM.
CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation
Vinit Kumar,Pingyan Cheng,Thomas Condamine,Sridevi Mony,Lucia R. Languino,Judith C. McCaffrey,Neil G. Hockstein,Michael J. Guarino,Gregory A. Masters,Emily Penman,Fred Denstman,Xiaowei Xu,Dario C. Altieri,Hong Du,Cong Yan,Dmitry I. Gabrilovich +15 more
TL;DR: In this article, the authors demonstrated that the differentiation of TAMs in tumor site from monocytic precursors was controlled by downregulation of the activity of the transcription factor STAT3.
Journal ArticleDOI
Activation of the Signal Transducers and Activators of the Transcription 3 Pathway in Alveolar Epithelial Cells Induces Inflammation and Adenocarcinomas in Mouse Lung
TL;DR: Stat3 is a potent proinflammatory molecule that directly causes spontaneous lung cancer in vivo and served as biomarkers for human bronchoalveolar adenocarcinoma during tumorigenesis.