K
Koichi Honke
Researcher at Kōchi University
Publications - 165
Citations - 6941
Koichi Honke is an academic researcher from Kōchi University. The author has contributed to research in topics: Cell culture & Receptor. The author has an hindex of 46, co-authored 163 publications receiving 6414 citations. Previous affiliations of Koichi Honke include Johns Hopkins University School of Medicine & Hokkaido University.
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Journal ArticleDOI
Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice
Xiangchun Wang,Shinya Inoue,Jianguo Gu,Eiji Miyoshi,Katsuhisa Noda,Wenzhe Li,Yoko Mizuno-Horikawa,Miyako Nakano,Michio Asahi,Motoko Takahashi,Motoko Takahashi,Naofumi Uozumi,Shinji Ihara,Seung Ho Lee,Yoshitaka Ikeda,Yoshitaka Ikeda,Yukihiro Yamaguchi,Yukihiro Yamaguchi,Yoshiya Aze,Yoshiaki Tomiyama,Junichi Fujii,Junichi Fujii,Keiichiro Suzuki,Keiichiro Suzuki,Akihiro Kondo,Steven D. Shapiro,Carlos López-Otín,Tomoyuki Kuwaki,Masaru Okabe,Koichi Honke,Koichi Honke,Naoyuki Taniguchi +31 more
TL;DR: It is proposed that the lack of core fucosylation of TGF-beta1 receptors is crucial for a developmental and progressive/destructive emphysema, suggesting that perturbation of this function could underlie certain cases of human emphySEma.
Journal ArticleDOI
Paranodal junction formation and spermatogenesis require sulfoglycolipids.
Koichi Honke,Yukie Hirahara,Jeffrey L. Dupree,Kinuko Suzuki,Brian Popko,Kikuro Fukushima,Junko Fukushima,Takashi Nagasawa,Nobuaki Yoshida,Yoshinao Wada,Naoyuki Taniguchi +10 more
TL;DR: Data show a critical role for sulfoglycolipids in myelin function and spermatogenesis in mice generated by gene targeting and whether sulfatide and seminolipid are biosynthesized in vivo by a single sulfotransferase.
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Core Fucosylation Regulates Epidermal Growth Factor Receptor-mediated Intracellular Signaling
TL;DR: It is found that the core fucosylation of N-glycans is required for the binding of the EGF to its receptor, whereas no effect was observed for the expression levels of EGFR on the cell surface.
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A Myelin Galactolipid, Sulfatide, Is Essential for Maintenance of Ion Channels on Myelinated Axon But Not Essential for Initial Cluster Formation
Tomoko Ishibashi,Jeffrey L. Dupree,Kazuhiro Ikenaka,Yukie Hirahara,Koichi Honke,Elior Peles,Brian Popko,Kinuko Suzuki,Hitoo Nishino,Hiroko Baba +9 more
TL;DR: Results indicate a critical role for sulfatide in proper localization and maintenance of ion channels clusters, whereas they do not appear to be essential for initial cluster formation of Na+ channels.
Journal ArticleDOI
Sulfatide is essential for the maintenance of CNS myelin and axon structure.
TL;DR: Although sulfatide appears to play a limited role in myelin development, this lipid is essential for myelin maintenance, as the prevalence of redundant, uncompacted, and degenerating myelin sheaths as well as deteriorating nodal/paranodal structure is increased significantly in aged sulfatides‐null mice as compared with littermate wildtype mice.