Constantine Frangakis

TL;DR: This paper provides an introduction to the MICE method with a focus on practical aspects and challenges in using this method.

TL;DR: Methods for preventing missing data and, failing that, dealing with data that are missing in clinical trials are reviewed.

TL;DR: This work proposes a general framework for comparing treatments adjusting for posttreatment variables that yields principal effects based on principal stratification and attacks the problem of surrogate or biomarker endpoints, where all current definitions of surrogacy do not generally have the desired interpretation as causal effects of treatment on outcome.

TL;DR: Among patients with probable Alzheimer disease and agitation who were receiving psychosocial intervention, the addition of citalopram compared with placebo significantly reduced agitation and caregiver distress; however, cognitive and cardiac adverse effects of cITALopram may limit its practical application at the dosage of 30 mg per day.

TL;DR: In this article, the combined impact of all-or-none compliance and subsequent missing outcomes can have on the estimation of the intention-to-treat effect of assignment in randomised studies.