Consuelo Barroso

TL;DR: It is concluded that HTP-1 is central to the mechanism linking crossovers with late-prophase bivalent differentiation and defines the domains where cohesion will be protected until meiosis II.

TL;DR: It is proposed that meiotic cohesin promotes DSB processing and recruitment of DNA damage checkpoint proteins, thus implicating cohesIn in the earliest steps of the DNA damage response during meiosis.

TL;DR: It is shown that during C. elegans oogenesis WAPL-1 antagonizes binding of cohesin containing COH-3/4 kleisins, but not REC-8, demonstrating that sensitivity to WAPl-1 is dictated by kleisin identity, and promotes functional specialization of meiosis-specific cohesInference, providing insight into how meiotic-specificCohesin complexes are regulated to ensure formation of euploid gametes.

TL;DR: In C. elegans oocytes, regulated recruitment of Aurora B kinase ensures the correct distribution of REC-8 phosphorylation, which promotes cohesion release, which elucidate a complex regulatory network that uses chromosome axis components, H3 T3 phosphorylated, and cell cycle regulators to ensure accurate chromosome segregation during oogenesis.

TL;DR: In this article, the authors employed single-molecule imaging to investigate the mechanism of nematode RAD-51 filament growth in the presence of BRC-2 (BRCA2) and RFS-1/RIP-1.