O
Ondrej Belan
Researcher at Francis Crick Institute
Publications - 11
Citations - 237
Ondrej Belan is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 4, co-authored 8 publications receiving 126 citations. Previous affiliations of Ondrej Belan include Masaryk University.
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Journal ArticleDOI
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.
Roberto Bellelli,Ondrej Belan,Valerie E. Pye,Camille Clement,Camille Clement,Sarah L. Maslen,J. Mark Skehel,Peter Cherepanov,Geneviève Almouzni,Geneviève Almouzni,Simon J. Boulton +10 more
TL;DR: This study reveals that POLE3-POLE4 possesses intrinsic H3-H4 chaperone activity, which facilitates faithful nucleosome dynamics at the replication fork.
Journal ArticleDOI
SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance.
Stephanie Panier,Marija Maric,Graeme Hewitt,Emily Mason-Osann,Himabindu Gali,Anqi Dai,Adam Labadorf,Jean-Hugues Guervilly,Philip Ruis,Sandra Segura-Bayona,Ondrej Belan,Paulina Marzec,Pierre-Henri L. Gaillard,Rachel Litman Flynn,Simon J. Boulton +14 more
TL;DR: It is shown that ALT recombination requires coordinate regulation of the SMX and BTR complexes to ensure the appropriate balance of resolution and dissolution activities at recombining telomeres, and an SLX4IP-dependent regulatory mechanism critical for telomere maintenance in ALT cancer cells is uncovered.
Journal ArticleDOI
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.
Ondrej Belan,Consuelo Barroso,Artur Kaczmarczyk,Roopesh Anand,Stefania Federico,Nicola O’Reilly,Matthew D. Newton,Erik Maeots,Radoslav I. Enchev,Enrique Martinez-Perez,David Rueda,Simon J. Boulton +11 more
TL;DR: In this article, the authors employed single-molecule imaging to investigate the mechanism of nematode RAD-51 filament growth in the presence of BRC-2 (BRCA2) and RFS-1/RIP-1.
Journal ArticleDOI
Cancer TARGETases: DSB repair as a pharmacological target
TL;DR: The various alternative approaches to target the various protein classes termed as cancer TARGETases in DSB repair pathway to obtain more beneficial and selective therapy are reviewed.
Posted ContentDOI
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins
Ondrej Belan,Consuelo Barroso,Artur Kaczmarczyk,Roopesh Anand,Stefania Federico,Nicola O’Reilly,Matthew D. Newton,Erik Maeots,Radoslav I. Enchev,Enrique Martinez-Perez,David Rueda,Simon J. Boulton +11 more
TL;DR: This work reveals the mechanism of RAD-51 nucleation and filament growth in the presence of recombination mediators, including BRC-2 and RFS-1/RIP-1, which promotes filament growth via highly dynamic engagement with 5’ filament ends.