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Artur Kaczmarczyk
Researcher at Leiden University
Publications - 13
Citations - 202
Artur Kaczmarczyk is an academic researcher from Leiden University. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 6, co-authored 11 publications receiving 105 citations. Previous affiliations of Artur Kaczmarczyk include Delft University of Technology & Imperial College London.
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Journal ArticleDOI
Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.
Ondrej Belan,Consuelo Barroso,Artur Kaczmarczyk,Roopesh Anand,Stefania Federico,Nicola O’Reilly,Matthew D. Newton,Erik Maeots,Radoslav I. Enchev,Enrique Martinez-Perez,David Rueda,Simon J. Boulton +11 more
TL;DR: In this article, the authors employed single-molecule imaging to investigate the mechanism of nematode RAD-51 filament growth in the presence of BRC-2 (BRCA2) and RFS-1/RIP-1.
Journal ArticleDOI
Chromatin fibers stabilize nucleosomes under torsional stress
Artur Kaczmarczyk,Artur Kaczmarczyk,Artur Kaczmarczyk,He Meng,Orkide Ordu,John van Noort,Nynke H. Dekker +6 more
TL;DR: The findings indicate that the supercoiling generated by DNA-processing enzymes, predicted by the twin-supercoiled domain model, can be largely accommodated by the higher-order structure of chromatin, suggesting that chromatin fibers stabilize nucleosomes under torsional stress.
Journal ArticleDOI
Single-molecule force spectroscopy on histone H4 tail-cross-linked chromatin reveals fiber folding
Artur Kaczmarczyk,Artur Kaczmarczyk,Abdollah Allahverdi,Thomas B. Brouwer,Lars Nordenskiöld,Nynke H. Dekker,John van Noort +6 more
TL;DR: These findings imply that chromatin compaction by nucleosome stacking protects nucleosomal DNA from external forces up to 4 piconewtons, and extend the understanding of chromatin structure and its potential roles in gene regulation.
Journal ArticleDOI
Rigid Basepair Monte Carlo Simulations of One-Start and Two-Start Chromatin Fiber Unfolding by Force.
TL;DR: The major insight is that nucleosome unstacking and subsequent unwrapping is not necessary to obtain quantitative agreement with experimental force extension curves up to the overstretching plateau of folded chromatin fibers at 3–5 pN.
Book ChapterDOI
Probing Chromatin Structure with Magnetic Tweezers.
Artur Kaczmarczyk,Artur Kaczmarczyk,Thomas B. Brouwer,Chi Pham,Nynke H. Dekker,John van Noort +5 more
TL;DR: Detailed methods are reported that allow one to successfully prepare in vitro reconstituted chromatin fibers for use in magnetic tweezers-based force spectroscopy, and can be extended to study many other processes involving chromatin, such as the epigenetic regulation of transcription.