R
Rabii Ameziane-El-Hassani
Researcher at Centre national de la recherche scientifique
Publications - 9
Citations - 671
Rabii Ameziane-El-Hassani is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Oxidative stress & NADPH oxidase. The author has an hindex of 9, co-authored 9 publications receiving 584 citations. Previous affiliations of Rabii Ameziane-El-Hassani include Institut Gustave Roussy & University of Paris.
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Journal ArticleDOI
Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.
Rabii Ameziane-El-Hassani,Stanislas Morand,Jean-Luc Boucher,Yves-Michel Frapart,Daphné Apostolou,Diane Agnandji,Sédami Gnidehou,Renée Ohayon,Marie-Sophie Noël-Hudson,Jacques Francon,Khalid Lalaoui,Alain Virion,Corinne Dupuy +12 more
TL;DR: It is demonstrated that the partially glycosylated form of Duox2, located in the endoplasmic reticulum, generates superoxide in a calcium-dependent manner and suggested that post-translational modifications during the maturation process of DuOX2 could be implicated in the mechanism of H2O2 formation by favoring intramolecular superoxide dismutation.
Journal ArticleDOI
Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues
Urbain Weyemi,Bernard Caillou,Monique Talbot,Monique Talbot,Rabii Ameziane-El-Hassani,Ludovic Lacroix,Odile Lagent-Chevallier,Odile Lagent-Chevallier,Odile Lagent-Chevallier,Abir Al Ghuzlan,Dirk Roos,Jean-Miche L. Bidart,Jean-Miche L. Bidart,Alai N. Virion,Alai N. Virion,Alai N. Virion,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy,Corinne Dupuy,Corinne Dupuy +20 more
TL;DR: Intracellular NOX4-p22(phox) localization suggests a role in cytoplasmic redox signaling, in contrast to the DUOX localization at the apical membrane that corresponds to an extracellular H( 2)O(2) production.
Journal ArticleDOI
NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation
Rabii Ameziane-El-Hassani,Rabii Ameziane-El-Hassani,Monique Talbot,Monique Talbot,Maria Carolina de Souza Dos Santos,Maria Carolina de Souza Dos Santos,Abir Al Ghuzlan,Abir Al Ghuzlan,Dana M. Hartl,Jean-Michel Bidart,Jean-Michel Bidart,Xavier De Deken,Françoise Miot,Ibrahima Diallo,Ibrahima Diallo,Florent de Vathaire,Florent de Vathaire,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy,Corinne Dupuy +20 more
TL;DR: Investigation of the mechanism by which IR induces the generation of reactive oxygen species (ROS) several days after irradiation focused on NADPH oxidases, which are specialized ROS-generating enzymes known as NOX/DUOX, revealing a key role of DUOX1-dependent H2O2 production in long-term persistent radio-induced DNA damage.
Journal ArticleDOI
Role of H2O2 in RET/PTC1 Chromosomal Rearrangement Produced by Ionizing Radiation in Human Thyroid Cells
Rabii Ameziane-El-Hassani,Myriem Boufraqech,Myriem Boufraqech,Odile Lagente-Chevallier,Odile Lagente-Chevallier,Urbain Weyemi,Monique Talbot,Monique Talbot,Didier Métivier,Didier Métivier,Françoise Courtin,Françoise Courtin,Jean Michel Bidart,Jean Michel Bidart,Mohammed El Mzibri,Martin Schlumberger,Martin Schlumberger,Corinne Dupuy,Corinne Dupuy +18 more
TL;DR: This study shows for the first time that H(2)O(2), generated during a 5 Gy X-ray irradiation, causes DNA double-strand breaks and contributes to RET/PTC1 formation in thyroid cells and highlights that oxidative stress could be responsible for the occurrence of RET/ PTC1 rearrangement found in thyroid lesions even in the absence of radiation exposure.
Journal ArticleDOI
NADPH Oxidase NOX4 Is a Critical Mediator of BRAFV600E-Induced Downregulation of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas
Naima Azouzi,Jérémy Cailloux,Jérémy Cailloux,Jérémy Cailloux,Juliana Cazarin,Jeffrey A. Knauf,Jennifer R. Cracchiolo,Abir Al Ghuzlan,Abir Al Ghuzlan,Abir Al Ghuzlan,Dana M. Hartl,Michel Polak,Aurore Carré,Mohammed El Mzibri,Abdelkarim Filali-Maltouf,Abderrahmane Al Bouzidi,Martin Schlumberger,Martin Schlumberger,Martin Schlumberger,James A. Fagin,Rabii Ameziane-El-Hassani,Rabii Ameziane-El-Hassani,Corinne Dupuy,Corinne Dupuy,Corinne Dupuy +24 more
TL;DR: It is shown that NOX4 upregulation is controlled at the transcriptional level by the oncogene via the TGF-β/Smad3 signaling pathway, suggestive of a potential role in BRAFV600E-induced thyroid tumors.