I
Imre Mäger
Researcher at University of Oxford
Publications - 67
Citations - 10180
Imre Mäger is an academic researcher from University of Oxford. The author has contributed to research in topics: Extracellular vesicle & RNA. The author has an hindex of 30, co-authored 63 publications receiving 7545 citations. Previous affiliations of Imre Mäger include Stockholm University & University of Tartu.
Papers
More filters
Journal ArticleDOI
Extracellular vesicles: biology and emerging therapeutic opportunities
TL;DR: Recent progress in understanding extracellular vesicle biology and the role of extrace cellular vesicles in disease is reviewed, emerging therapeutic opportunities are discussed and the associated challenges are considered.
Journal ArticleDOI
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Oscar P. B. Wiklander,Joel Z. Nordin,Aisling J. O’Loughlin,Ylva Gustafsson,Giulia Corso,Imre Mäger,Pieter Vader,Yi Lee,Helena Sork,Yiqi Seow,Nina Heldring,Lydia Alvarez-Erviti,C. I. Edvard Smith,Katarina Le Blanc,Paolo Macchiarini,Philipp Jungebluth,Matthew J.A. Wood,Samir El Andaloussi +17 more
TL;DR: This is the first extensive biodistribution investigation of EVs comparing the impact of several different variables, the results of which have implications for the design and feasibility of therapeutic studies using EVs.
Journal ArticleDOI
Cells release subpopulations of exosomes with distinct molecular and biological properties
Eduard Willms,Henrik J. Johansson,Imre Mäger,Imre Mäger,Yi Lee,K. Emelie M. Blomberg,Mariam Sadik,Amr Alaarg,C. I. Edvard Smith,Janne Lehtiö,Samir El Andaloussi,Samir El Andaloussi,Matthew J.A. Wood,Pieter Vader,Pieter Vader +14 more
TL;DR: It is demonstrated that cells release distinct exosome subpopulations with unique compositions that elicit differential effects on recipient cells that will advance the understanding of exosomal biology in health and disease and accelerate the development ofExosome-based diagnostics and therapeutics.
Journal ArticleDOI
Methodological Guidelines to Study Extracellular Vesicles.
Frank A. W. Coumans,Alain Brisson,Edit I. Buzás,Françoise Dignat-George,Esther E.E. Drees,Samir El-Andaloussi,Samir El-Andaloussi,Costanza Emanueli,Costanza Emanueli,Aleksandra Gasecka,Aleksandra Gasecka,An Hendrix,Andrew F. Hill,Romaric Lacroix,Yi Lee,Ton G. van Leeuwen,Nigel Mackman,Imre Mäger,Imre Mäger,John P. Nolan,Edwin van der Pol,D. Michiel Pegtel,Susmita Sahoo,Pia Siljander,Guus Sturk,Olivier De Wever,Rienk Nieuwland +26 more
TL;DR: This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs.
Journal ArticleDOI
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper
Bogdan Mateescu,Emma J. K. Kowal,Bas W.M. van Balkom,Sabine Bartel,Suvendra N. Bhattacharyya,Edit I. Buzás,Amy H. Buck,Paola de Candia,Franklin Wang Ngai Chow,Saumya Das,Tom A. P. Driedonks,Lola Fernández-Messina,Franziska Haderk,Andrew F. Hill,Jennifer Jones,Kendall Van Keuren-Jensen,Charles P. Lai,Cecilia Lässer,Italia Di Liegro,Taral R. Lunavat,Magdalena J. Lorenowicz,Sybren L. N. Maas,Imre Mäger,María Mittelbrunn,Stefan Momma,Kamalika Mukherjee,Muhammad Nawaz,D. Michiel Pegtel,Michael W. Pfaffl,Raymond M. Schiffelers,Hidetoshi Tahara,Clotilde Théry,Juan Pablo Tosar,Marca H. M. Wauben,Kenneth W. Witwer,Esther N. M. Nolte-‘t Hoen +35 more
TL;DR: This position paper was written by the participants of the workshop to give an overview of the current state of knowledge in the field and to clarify that incomplete knowledge – of the nature of EV(-RNA)s and of how to effectively and reliably study them – currently prohibits the implementation of gold standards in EV-RNA research.