S
Samir El-Andaloussi
Researcher at Karolinska Institutet
Publications - 37
Citations - 5420
Samir El-Andaloussi is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Small interfering RNA & Drug delivery. The author has an hindex of 24, co-authored 36 publications receiving 4541 citations. Previous affiliations of Samir El-Andaloussi include Karolinska University Hospital & University of Oxford.
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PatentDOI
Cell Penetrating Peptides
Mattias Hällbrink,Margus Pooga,Madis Tallin Unive Metsis,Priit Kogerman,Andreas Valkna,Anne Meikas,Maria Lindgren,Astrid Gräslund,Göran Eriksson,Claes Göran Östensson,Metka V. Budihna,Matjaz Zorko,Anna Elmquist,Ursel Soomets,Pontus Lundberg,Peter Järver,Külliki Saar,Samir El-Andaloussi,Kalle Kilk,Ülo Langel +19 more
TL;DR: In this paper, a method for predicting or designing, detecting, and/or verifying a novel cell-penetrating peptide (CPP) was proposed and used for treating and preventing a medical condition.
Journal ArticleDOI
Methodological Guidelines to Study Extracellular Vesicles.
Frank A. W. Coumans,Alain Brisson,Edit I. Buzás,Françoise Dignat-George,Esther E.E. Drees,Samir El-Andaloussi,Samir El-Andaloussi,Costanza Emanueli,Costanza Emanueli,Aleksandra Gasecka,Aleksandra Gasecka,An Hendrix,Andrew F. Hill,Romaric Lacroix,Yi Lee,Ton G. van Leeuwen,Nigel Mackman,Imre Mäger,Imre Mäger,John P. Nolan,Edwin van der Pol,D. Michiel Pegtel,Susmita Sahoo,Pia Siljander,Guus Sturk,Olivier De Wever,Rienk Nieuwland +26 more
TL;DR: This review provides an expert-based update of recent advances in the methods to study EVs and summarizes currently accepted considerations and recommendations from sample collection to isolation, detection, and characterization of EVs.
Journal ArticleDOI
Exosome-mediated delivery of siRNA in vitro and in vivo
Samir El-Andaloussi,Samir El-Andaloussi,Yi Lee,Samira Lakhal-Littleton,Jinghuan Li,Yiqi Seow,Chris Gardiner,Lydia Alvarez-Erviti,I L Sargent,Matthew J.A. Wood +9 more
TL;DR: This protocol describes the generation of targeted exosomes through transfection of an expression vector, comprising an exosomal protein fused with a peptide ligand, and details crucial steps for loading siRNA into exosome.
Journal ArticleDOI
Comprehensive proteomic analysis of mesenchymal stem cell exosomes reveals modulation of angiogenesis via nuclear factor-kappaB signaling
Johnathon D. Anderson,Henrik J. Johansson,Calvin S. Graham,Mattias Vesterlund,Missy T. Pham,Charles S. Bramlett,Elizabeth N. Montgomery,Matt S. Mellema,Renee L. Bardini,Zelenia Contreras,Madeline Hoon,Gerhard Bauer,Kyle D. Fink,Brian Fury,Kyle Hendrix,Frédéric Chédin,Samir El-Andaloussi,Billie Hwang,Michael S. Mulligan,Janne Lehtiö,Jan A. Nolta +20 more
TL;DR: The results of the proteomic analysis show that MSC derived exosomes contain a robust profile of angiogenic paracrine effectors, which have potential for the treatment of ischemic tissue‐related diseases.
Journal ArticleDOI
Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.
J M Cooper,PB Wiklander,Joel Z. Nordin,R Al-Shawi,Matthew J.A. Wood,M Vithlani,Anthony H.V. Schapira,JP Simons,Samir El-Andaloussi,Lydia Alvarez-Erviti +9 more
TL;DR: This study highlights the therapeutic potential of RVG‐exosome delivery of siRNA to delay and reverse brain α‐Syn pathological conditions.