Craig N. Giroux

TL;DR: These findings strongly implicate Spo11 as the catalytic subunit of the meiotic DNA cleavage activity and provide direct evidence that the mechanism of meiotic recombination initiation is evolutionarily conserved.

TL;DR: 12-HETER represents the first identified high affinity receptor for the 12-(S)-HETE hydroxyl fatty acids and leads to activation of ERK1/2, MEK, and NFκB.

TL;DR: Results here bring further understanding to the potential for molecular differences for PCa in AAM versus EAM and support the notion that therapeutic benefits will be realized when targeted treatments are designed to acknowledge and address a greater spectrum of PCa subtypes and molecular distinctions.

TL;DR: This study systematically investigated the transforming properties of 13 newly identified 8p11-12 candidate oncogenes in vitro and identified several WHSC1L1 target genes, one of which is iroquoisHomeobox 3 gene (IRX3), a member of the Iroquois homeobox transcription factor family.

TL;DR: Inflammatory pathway genotypes may serve to define a high risk group; further exploration of these genes in minority populations is warranted.