M
Michele L. Cote
Researcher at Wayne State University
Publications - 180
Citations - 6802
Michele L. Cote is an academic researcher from Wayne State University. The author has contributed to research in topics: Population & Lung cancer. The author has an hindex of 38, co-authored 168 publications receiving 5422 citations. Previous affiliations of Michele L. Cote include George Washington University & University of Michigan.
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Journal ArticleDOI
ATM Mutations in Patients with Hereditary Pancreatic Cancer
Nicholas J. Roberts,Yuchen Jiao,Jun Yu,Levy Kopelovich,Gloria M. Petersen,Melissa L. Bondy,Steven Gallinger,Ann G. Schwartz,Sapna Syngal,Michele L. Cote,Jennifer E. Axilbund,Richard D. Schulick,Syed Z. Ali,James R. Eshleman,Victor E. Velculescu,Michael Goggins,Bert Vogelstein,Nickolas Papadopoulos,Ralph H. Hruban,Kenneth W. Kinzler,Alison P. Klein +20 more
TL;DR: Next-generation sequencing is used, including whole-genome and whole-exome analyses, and heterozygous, constitutional, ataxia telangiectasia mutated (ATM) gene mutations in 2 kindreds with familial pancreatic cancer are identified, indicating that inherited ATM mutations play an important role in familial Pancreatic cancer predisposition.
Journal ArticleDOI
Cancer Progress and Priorities: Lung Cancer
TL;DR: In the United States, lung cancer is the second most common diagnosed cancer and the leading cause of cancer-related death and the major risk factor is tobacco smoking.
Journal ArticleDOI
Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer
Nicholas J. Roberts,Alexis L. Norris,Gloria M. Petersen,Melissa L. Bondy,Randall E. Brand,Steven Gallinger,Robert C. Kurtz,Sara H. Olson,Anil K. Rustgi,Ann G. Schwartz,Elena M. Stoffel,Sapna Syngal,George Zogopoulos,Syed Z. Ali,Jennifer E. Axilbund,Kari G. Chaffee,Yun-Ching Chen,Michele L. Cote,Erica J. Childs,Christopher Douville,Fernando S. Goes,Joseph M. Herman,Christine A. Iacobuzio-Donahue,Melissa Kramer,Alvin Makohon-Moore,Richard W. McCombie,K. Wyatt McMahon,Noushin Niknafs,Jennifer Parla,Mehdi Pirooznia,James B. Potash,Andrew D. Rhim,Andrew D. Rhim,Alyssa L. Smith,Yuxuan Wang,Christopher L. Wolfgang,Laura D. Wood,Peter P. Zandi,Michael Goggins,Rachel Karchin,James R. Eshleman,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Ralph H. Hruban,Alison P. Klein +45 more
TL;DR: It is demonstrated that the genetic underpinning of inherited pancreatic cancer is highly heterogeneous, which has significant implications for the management of patients with familial Pancreatic cancer and for the identification of susceptibility genes in other common cancer types.
Journal ArticleDOI
Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010
TL;DR: Lung cancer incidence in the United States continues to decrease but with significant differences by histology, gender and race, whereas adenocarcinoma rates remain relatively constant in males and increasing in females.
Journal ArticleDOI
BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: A PACGENE study
David B. Zhen,Kari G. Rabe,Steven Gallinger,Sapna Syngal,Ann G. Schwartz,Michael Goggins,Ralph H. Hruban,Michele L. Cote,Robert R. McWilliams,Nicholas J. Roberts,Lisa A. Cannon-Albright,Donghui Li,Kelsey Moyes,Richard J. Wenstrup,Anne Renee Hartman,Daniela Seminara,Alison P. Klein,Gloria M. Petersen +17 more
TL;DR: Genetic testing of multiple relevant genes in probands with a positive family history is warranted, particularly for familial pancreatic cancer, which contains at least two affected first-degree relatives.