Angie S. Wenzlaff

TL;DR: Previous associations found in white populations were replicated and new associations were identified in Asian populations, and the associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest for squamous cell carcinomas.

TL;DR: This population-based study evaluates polymorphisms in both of these CYP genes within never smokers, most of whom had environmental tobacco smoke exposure, and found that CYP1B1 Leu(432)Val alone and in combination with Phase II enzyme polymorphisms was more strongly associated with increased lung cancer susceptibility among those with at least some household ETS exposure.

TL;DR: It is suggested that in the presence of ETS, the GSTM1 genotype both alone and in combination with the GSTP1 genotypes alters the risk of developing lung cancer among never smokers.

TL;DR: It is suggested that racial groups are not simplistically represented by a pro-inflammatory or anti-inflammatory genetic profile and studies examining the association between these SNPs and disease should at least incorporate self-reported race in their analyses.

TL;DR: In this paper, the observed consistent association of rs16969968 with heavy smoking across multiple populations, combined with its known biological significance, suggests it is most likely a functional variant that alters risk for heavy smoking.