C
Crissy Phillips
Researcher at National Institutes of Health
Publications - 4
Citations - 1028
Crissy Phillips is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Phosphorylation & Phosphatase. The author has an hindex of 4, co-authored 4 publications receiving 989 citations.
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Journal ArticleDOI
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
Dmitry V. Bulavin,Oleg N. Demidov,Shin'ichi Saito,Päivikki Kauraniemi,Päivikki Kauraniemi,Crissy Phillips,Sally A. Amundson,Concetta Ambrosino,Guido Sauter,Angel R. Nebreda,Carl W. Anderson,Anne Kallioniemi,Albert J. Fornace,Ettore Appella +13 more
TL;DR: Findings suggest that inactivation of the p38 MAPK through PPM1D overexpression resulting from P PM1D amplification contributes to the development of human cancers by suppressing p53 activation.
Journal ArticleDOI
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Dmitry V. Bulavin,Crissy Phillips,Bonnie Nannenga,Oleg Timofeev,Lawrence A. Donehower,Carl W. Anderson,Ettore Appella,Albert J. Fornace +7 more
TL;DR: It is concluded that inactivation or depletion of the Wip1 phosphatase with resultant p38 MAPK activation suppresses tumor appearance by modulating the Cdkn2a tumor-suppressor locus.
Journal ArticleDOI
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
Dmitry V. Bulavin,Yuichiro Higashimoto,Zoya N. Demidenko,Sarah E. M. Meek,Paul R. Graves,Paul R. Graves,Crissy Phillips,Hui Zhao,Sally A. Moody,Ettore Appella,Helen Piwnica-Worms,Albert J. Fornace +11 more
TL;DR: It is shown that Cdc25C is phosphorylated on Ser 214 during mitosis, which in turn prevents phosphorylation of Ser 216, which is a key control mechanism for maintaining the proper order of cell-cycle transitions.
Journal ArticleDOI
Phosphorylation of Xenopus Cdc25C at Ser285 Interferes with Ability to Activate a DNA Damage Replication Checkpoint in the Pre-Midblastula Embryos
TL;DR: It is proposed that phosphorylation of XeCdc25C Ser285 may account for the lack of a DNA replication checkpoint in cleaving Xenopus embryos prior to the Midblastula Transition (MBT).