Y
Yuichiro Higashimoto
Researcher at Kurume University
Publications - 100
Citations - 7584
Yuichiro Higashimoto is an academic researcher from Kurume University. The author has contributed to research in topics: Heme & Glycation. The author has an hindex of 35, co-authored 98 publications receiving 7113 citations. Previous affiliations of Yuichiro Higashimoto include Saga Group & University of Texas Health Science Center at Tyler.
Papers
More filters
Journal ArticleDOI
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
Mark Pearson,Roberta Carbone,Carla Sebastiani,Mario Cioce,Marta Fagioli,Shin'ichi Saito,Yuichiro Higashimoto,Ettore Appella,Saverio Minucci,Pier Paolo Pandolfi,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci +11 more
TL;DR: It is found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence in a p53-dependent manner, and integrity of the PML bodies is required for p53 acetylation and senescences upon oncogene expression.
Journal ArticleDOI
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
Gabriella D'Orazi,Barbara Cecchinelli,Tiziana Bruno,Isabella Manni,Yuichiro Higashimoto,Shin'ichi Saito,Monica Gostissa,Sabrina Coen,Alessandra Marchetti,Giannino Del Sal,Giulia Piaggio,Maurizio Fanciulli,Ettore Appella,Silvia Soddu +13 more
TL;DR: Homeodomain-interacting protein kinase-2 (HIPK2), a member of a novel family of nuclear serine/threonine kinases, binds to and activates p53 by directly phosphorylating it at Ser 46 and results in the targeted subcellular localization of p53 and initiation of apoptosis.
Journal ArticleDOI
MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation
Akihiro Ito,Yoshiharu Kawaguchi,Chun-Hsiang Lai,Jeffrey J. Kovacs,Yuichiro Higashimoto,Ettore Appella,Tso-Pang Yao +6 more
TL;DR: The results suggest that one major function of p53 acetylation is to promote p53 stability by preventingMDM2‐dependent ubiquitylation, while recruitment of HDAC1 by MDM2 promotes p53 degradation by removing these acetyl groups.
Journal ArticleDOI
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
Dmitry V. Bulavin,Yuichiro Higashimoto,Ian Popoff,William A. Gaarde,Venkatesha Basrur,Olga Potapova,Ettore Appella,Albert J. Fornace +7 more
TL;DR: It is reported that p38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation, and regulation of Cdc25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet Radiation.
Journal ArticleDOI
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Lorne J. Hofseth,Shin'ichi Saito,S. Perwez Hussain,Michael Graham Espey,Katrina M. Miranda,Yuzuru Araki,Chamelli Jhappan,Yuichiro Higashimoto,Peijun He,Steven P. Linke,Martha Quezado,Irit Zurer,Varda Rotter,David A. Wink,Ettore Appella,Curtis C. Harris +15 more
TL;DR: In noncancerous colon tissues from patients with ulcerative colitis, inducible NO synthase protein levels were positively correlated with p53 serine 15 phosphorylation levels, and Immunostaining of HDM-2 and p21WAF1 was consistent with transcriptionally active p53.