C
Cristian Prieto-Garcia
Researcher at University of Würzburg
Publications - 5
Citations - 43
Cristian Prieto-Garcia is an academic researcher from University of Würzburg. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 1, co-authored 5 publications receiving 5 citations. Previous affiliations of Cristian Prieto-Garcia include Technion – Israel Institute of Technology.
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Journal ArticleDOI
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.
Oliver Hartmann,Michaela Reissland,Carina R. Maier,Thomas Fischer,Cristian Prieto-Garcia,Cristian Prieto-Garcia,Apoorva Baluapuri,Jessica Denise Schwarz,Werner Schmitz,Martín Garrido-Rodríguez,Nikolett Pahor,Clare C. Davies,Florian Bassermann,Amir Orian,Elmar Wolf,Almut Schulze,Marco A. Calzado,Mathias T. Rosenfeldt,Markus E. Diefenbacher +18 more
TL;DR: In this paper, the authors used CRISPR/Cas9-mediated targeting of Trp53 and KRas in lung cancer patients to develop tumor models with similar morphology, marker expression and transcriptional profiles.
Journal ArticleDOI
Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway.
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Thomas Fischer,Carina R. Maier,Mathias Rosenfeldt,Christina Schülein-Völk,Kevin Klann,Reinhard Kalb,Ivan Dikic,Christian Münch,Markus E. Diefenbacher +11 more
TL;DR: In this article, the deubiquitylase USP28 is recruited to sites of DNA damage in cisplatin-treated cells, which stabilizes ∆Np63.
Posted ContentDOI
Inhibition of USP28 overcomes Cisplatin-Resistance of Squamous Tumors by Suppression of the Fanconi Anemia Pathway
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Thomas Fischer,Carina R. Maier,Mathias Rosenfeldt,Christina Schuelein-Voelk,Kevin Klann,Reinhard Kalb,Ivan Dikic,C. Muench,Markus E. Diefenbacher +11 more
TL;DR: This study reports that the deubiquitylase USP28 affects the FA DNA repair pathway during cisplatin treatment in SCC, thereby influencing therapy outcome, and presents a novel mechanism by which tumor cells, and in particular ΔNp63 expressing S CC, can be targeted to overcome chemotherapy resistance.
Posted ContentDOI
PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapy
Thomas Fischer,Oliver Hartmann,Michaela Reissland,Cristian Prieto-Garcia,Kevin Klann,Christina Schuelein-Voelk,Bülent Polat,E. Gebhard-Hartmann,Mathias Rosenfeldt,C. Muench,M. Flentje,Markus E. Diefenbacher +11 more
TL;DR: PTEN tumors are addicted to ATM to detect and repair radiation induced DNA damage, which creates an exploitable bottleneck and low concentration of ATM inhibitor is able to synergise with IR to treat PTEN-deficient tumors in genetically well-defined IR resistant lung cancer models.
Posted ContentDOI
The USP28-ΔNp63 axis is a vulnerability of squamous tumours
Cristian Prieto-Garcia,Oliver Hartmann,Michaela Reissland,Fabian Braun,Thomas Fischer,Susanne Walz,Annalena Fischer,Marco A. Calzado,Amir Orian,Mathias T. Rosenfeldt,Martin Eilers,Markus E. Diefenbacher +11 more
TL;DR: The deubiquitylase USP28 stabilizes ΔNp63 protein and maintains elevated ΔNP63 levels in SCC by counteracting its proteasome-mediated degradation, demonstrating the dependence of SCC for various human SCC in vitro and in vivo using murine lung tumour models.